BRD-K14821540_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K14821540_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BLNK B-cell linker
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTK Bruton agammaglobulinemia tyrosine kinase
CD22 CD22 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD79A CD79a molecule, immunoglobulin-associated alpha
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC7A C-type lectin domain family 7, member A
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
LY96 lymphocyte antigen 96
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MBNL2 muscleblind-like splicing regulator 2
PAX5 paired box 5
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKCI protein kinase C, iota
PSAT1 phosphoserine aminotransferase 1
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SKAP2 src kinase associated phosphoprotein 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFF1 trefoil factor 1
VPREB3 pre-B lymphocyte 3
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BMP4 bone morphogenetic protein 4
FSTL1 follistatin-like 1
GNAS GNAS complex locus
H2AFX H2A histone family, member X
HLA-B major histocompatibility complex, class I, B
HSPA8 heat shock 70kDa protein 8
IQGAP2 IQ motif containing GTPase activating protein 2
MMP12 matrix metallopeptidase 12
NELL2 NEL-like 2 (chicken)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
PEBP1 phosphatidylethanolamine binding protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PUF60 poly-U binding splicing factor 60KDa
RHOB ras homolog family member B
S100A10 S100 calcium binding protein A10
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
WNT5A wingless-type MMTV integration site family, member 5A