BRD-K14821540_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K14821540_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
AUH AU RNA binding protein/enoyl-CoA hydratase
BACE2 beta-site APP-cleaving enzyme 2
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD52 CD52 molecule
CD9 CD9 molecule
CDKN2AIP CDKN2A interacting protein
CENPU centromere protein U
CHIC2 cysteine-rich hydrophobic domain 2
CLEC11A C-type lectin domain family 11, member A
CPM carboxypeptidase M
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
ELOVL5 ELOVL fatty acid elongase 5
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCC2 GRIP and coiled-coil domain containing 2
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GMPR guanosine monophosphate reductase
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST3H2A histone cluster 3, H2a
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS2 insulin receptor substrate 2
ISYNA1 inositol-3-phosphate synthase 1
JUNB jun B proto-oncogene
KDM7A lysine (K)-specific demethylase 7A
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL1 muscleblind-like splicing regulator 1
MMP12 matrix metallopeptidase 12
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NPY neuropeptide Y
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRC protein tyrosine phosphatase, receptor type, C
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
RYBP RING1 and YY1 binding protein
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SIRT1 sirtuin 1
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
STK17A serine/threonine kinase 17a
SYT1 synaptotagmin I
TANK TRAF family member-associated NFKB activator
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
USP15 ubiquitin specific peptidase 15
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
XBP1 X-box binding protein 1
ZFAND6 zinc finger, AN1-type domain 6
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AK1 adenylate kinase 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BLCAP bladder cancer associated protein
C6ORF62 chromosome 6 open reading frame 62
CD14 CD14 molecule
CD163 CD163 molecule
CD93 CD93 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHPT1 choline phosphotransferase 1
CPVL carboxypeptidase, vitellogenic-like
CYBB cytochrome b-245, beta polypeptide
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
FAM198B family with sequence similarity 198, member B
FCGBP Fc fragment of IgG binding protein
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FKSG49 FKSG49
FN1 fibronectin 1
FPR1 formyl peptide receptor 1
FXYD6 FXYD domain containing ion transport regulator 6
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBB hemoglobin, beta
KCTD12 potassium channel tetramerization domain containing 12
KIF5C kinesin family member 5C
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
METRN meteorin, glial cell differentiation regulator
NT5DC2 5'-nucleotidase domain containing 2
ODAM odontogenic, ameloblast asssociated
OPHN1 oligophrenin 1
PIP prolactin-induced protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PSPH phosphoserine phosphatase
PXMP2 peroxisomal membrane protein 2, 22kDa
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SET SET nuclear proto-oncogene
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TLR4 toll-like receptor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TRIL TLR4 interactor with leucine-rich repeats
TUBB tubulin, beta class I
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding