BRD-K14920963_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K14920963_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAMDEC1 ADAM-like, decysin 1
ADM adrenomedullin
AFP alpha-fetoprotein
ASCL1 achaete-scute family bHLH transcription factor 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CRABP1 cellular retinoic acid binding protein 1
DBT dihydrolipoamide branched chain transacylase E2
DLK1 delta-like 1 homolog (Drosophila)
FBXO11 F-box protein 11
FN1 fibronectin 1
GPC3 glypican 3
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPK13 mitogen-activated protein kinase 13
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
PPAP2B phosphatidic acid phosphatase type 2B
PRPS2 phosphoribosyl pyrophosphate synthetase 2
QPRT quinolinate phosphoribosyltransferase
RET ret proto-oncogene
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SOCS1 suppressor of cytokine signaling 1
SOSTDC1 sclerostin domain containing 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ACTB actin, beta
ADAM10 ADAM metallopeptidase domain 10
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANAPC5 anaphase promoting complex subunit 5
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
CALU calumenin
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CNN3 calponin 3, acidic
COPA coatomer protein complex, subunit alpha
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
EXOC5 exocyst complex component 5
EZR ezrin
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GTF2I general transcription factor IIi
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
KRT7 keratin 7, type II
MCL1 myeloid cell leukemia 1
MCM4 minichromosome maintenance complex component 4
MRPS16 mitochondrial ribosomal protein S16
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRNP prion protein
PTBP1 polypyrimidine tract binding protein 1
RHOB ras homolog family member B
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRM1 ribonucleotide reductase M1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SRSF1 serine/arginine-rich splicing factor 1
STIP1 stress-induced phosphoprotein 1
SYPL1 synaptophysin-like 1
TACSTD2 tumor-associated calcium signal transducer 2
TKT transketolase
TMED2 transmembrane emp24 domain trafficking protein 2
TMX1 thioredoxin-related transmembrane protein 1
WDR1 WD repeat domain 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding