BRD-K15616905_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K15616905_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ANKRD11 ankyrin repeat domain 11
ANXA1 annexin A1
ANXA10 annexin A10
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C10ORF10 chromosome 10 open reading frame 10
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
COL8A2 collagen, type VIII, alpha 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DOK5 docking protein 5
EIF5 eukaryotic translation initiation factor 5
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FN1 fibronectin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GATA3 GATA binding protein 3
GFPT1 glutamine--fructose-6-phosphate transaminase 1
IFRD1 interferon-related developmental regulator 1
INHBE inhibin, beta E
ITM2A integral membrane protein 2A
JAG1 jagged 1
KRT14 keratin 14, type I
KRT18 keratin 18, type I
LARP6 La ribonucleoprotein domain family, member 6
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPC1 Niemann-Pick disease, type C1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTPRO protein tyrosine phosphatase, receptor type, O
RNASE4 ribonuclease, RNase A family, 4
SARS seryl-tRNA synthetase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
TFF3 trefoil factor 3 (intestinal)
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
AMACR alpha-methylacyl-CoA racemase
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
CBR1 carbonyl reductase 1
CCNF cyclin F
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EMP3 epithelial membrane protein 3
GPNMB glycoprotein (transmembrane) nmb
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS2 mitochondrial ribosomal protein S2
MSH6 mutS homolog 6
MXRA7 matrix-remodelling associated 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
PGAM1 phosphoglycerate mutase 1 (brain)
PLK1 polo-like kinase 1
QDPR quinoid dihydropteridine reductase
RPS4Y1 ribosomal protein S4, Y-linked 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TGFBI transforming growth factor, beta-induced, 68kDa
ZMYND8 zinc finger, MYND-type containing 8