BRD-K15716662_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-K15716662_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADIRF adipogenesis regulatory factor
AMDHD2 amidohydrolase domain containing 2
ARHGAP29 Rho GTPase activating protein 29
BST2 bone marrow stromal cell antigen 2
BTK Bruton agammaglobulinemia tyrosine kinase
C14ORF132 chromosome 14 open reading frame 132
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFD complement factor D (adipsin)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
LAGE3 L antigen family, member 3
MT1E metallothionein 1E
NDRG1 N-myc downstream regulated 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
RGS2 regulator of G-protein signaling 2
RPL10 ribosomal protein L10
RPS4Y1 ribosomal protein S4, Y-linked 1
TP53 tumor protein p53
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ANKRD10 ankyrin repeat domain 10
AURKA aurora kinase A
CADPS2 Ca++-dependent secretion activator 2
CCNB1 cyclin B1
CCNF cyclin F
CPE carboxypeptidase E
DKK1 dickkopf WNT signaling pathway inhibitor 1
EMX2 empty spiracles homeobox 2
GNAS GNAS complex locus
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2AC histone cluster 1, H2ac
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
PEG3 paternally expressed 3
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SULF1 sulfatase 1
THBS1 thrombospondin 1
TKTL1 transketolase-like 1
VCAN versican
XIST X inactive specific transcript (non-protein coding)