BRD-K15716662_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K15716662_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP11B ATPase, class VI, type 11B
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
EMP1 epithelial membrane protein 1
FADS1 fatty acid desaturase 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FSD1 fibronectin type III and SPRY domain containing 1
GCH1 GTP cyclohydrolase 1
GPM6B glycoprotein M6B
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDE2A phosphodiesterase 2A, cGMP-stimulated
PHYH phytanoyl-CoA 2-hydroxylase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RHOB ras homolog family member B
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SST somatostatin
TFF3 trefoil factor 3 (intestinal)
TMEM45A transmembrane protein 45A
TSC22D3 TSC22 domain family, member 3
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
AIM1 absent in melanoma 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKRD10 ankyrin repeat domain 10
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CADPS2 Ca++-dependent secretion activator 2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CNOT4 CCR4-NOT transcription complex, subunit 4
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
DENND1B DENN/MADD domain containing 1B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP22 dual specificity phosphatase 22
FASTKD5 FAST kinase domains 5
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
JADE2 jade family PHD finger 2
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PON3 paraoxonase 3
SSR1 signal sequence receptor, alpha
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TOR1A torsin family 1, member A (torsin A)
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE3C ubiquitin protein ligase E3C
ZSCAN31 zinc finger and SCAN domain containing 31
Funding