BRD-K16189898_CHIR-99021_MCF10A_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K16189898_CHIR-99021_MCF10A_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCK3 aarF domain containing kinase 3
AEBP1 AE binding protein 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BCHE butyrylcholinesterase
CELF2 CUGBP, Elav-like family member 2
CERS6 ceramide synthase 6
CKAP4 cytoskeleton-associated protein 4
CORO1A coronin, actin binding protein, 1A
CPA3 carboxypeptidase A3 (mast cell)
CPD carboxypeptidase D
CRELD2 cysteine-rich with EGF-like domains 2
CTSK cathepsin K
DSP desmoplakin
EPN2 epsin 2
FABP4 fatty acid binding protein 4, adipocyte
FBN2 fibrillin 2
G0S2 G0/G1 switch 2
IGFBP4 insulin-like growth factor binding protein 4
IL1RAP interleukin 1 receptor accessory protein
IRX5 iroquois homeobox 5
LRRC16A leucine rich repeat containing 16A
MYO1B myosin IB
NR2F6 nuclear receptor subfamily 2, group F, member 6
POSTN periostin, osteoblast specific factor
RBP1 retinol binding protein 1, cellular
SH3BP4 SH3-domain binding protein 4
SLC43A3 solute carrier family 43, member 3
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
STK10 serine/threonine kinase 10
THBD thrombomodulin
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TPD52 tumor protein D52
VCAN versican

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ADIRF adipogenesis regulatory factor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
AQP3 aquaporin 3 (Gill blood group)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BHLHE41 basic helix-loop-helix family, member e41
CBR3 carbonyl reductase 3
CLIC5 chloride intracellular channel 5
CRABP1 cellular retinoic acid binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DENND2D DENN/MADD domain containing 2D
EDN3 endothelin 3
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
FXYD2 FXYD domain containing ion transport regulator 2
G6PD glucose-6-phosphate dehydrogenase
GRB7 growth factor receptor-bound protein 7
GSN gelsolin
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
MME membrane metallo-endopeptidase
MSLN mesothelin
NDP Norrie disease (pseudoglioma)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PCBP2 poly(rC) binding protein 2
PLAGL1 pleiomorphic adenoma gene-like 1
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100P S100 calcium binding protein P
SELENBP1 selenium binding protein 1
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STK17A serine/threonine kinase 17a
SYNE2 spectrin repeat containing, nuclear envelope 2
TACC1 transforming, acidic coiled-coil containing protein 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR3 transforming growth factor, beta receptor III
TOX thymocyte selection-associated high mobility group box
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM29 tripartite motif containing 29
TSC22D1 TSC22 domain family, member 1
VCAM1 vascular cell adhesion molecule 1
WT1 Wilms tumor 1
ZBTB20 zinc finger and BTB domain containing 20
Funding