BRD-K16277217_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K16277217_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CHMP4A charged multivesicular body protein 4A
CHN1 chimerin 1
CLC Charcot-Leyden crystal galectin
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXORF57 chromosome X open reading frame 57
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EED embryonic ectoderm development
EGF epidermal growth factor
EMP2 epithelial membrane protein 2
FAM129A family with sequence similarity 129, member A
FOLR1 folate receptor 1 (adult)
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INSM1 insulinoma-associated 1
IRF6 interferon regulatory factor 6
KCNK3 potassium channel, two pore domain subfamily K, member 3
KRT20 keratin 20, type I
LOC100272216 uncharacterized LOC100272216
LOC100505650 uncharacterized LOC100505650
MATN2 matrilin 2
MEIS1 Meis homeobox 1
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
NLRP2 NLR family, pyrin domain containing 2
NR0B1 nuclear receptor subfamily 0, group B, member 1
NRCAM neuronal cell adhesion molecule
NTS neurotensin
OLFM1 olfactomedin 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PERP PERP, TP53 apoptosis effector
PGAP1 post-GPI attachment to proteins 1
POLQ polymerase (DNA directed), theta
PRKCI protein kinase C, iota
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB31 RAB31, member RAS oncogene family
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCGB2A2 secretoglobin, family 2A, member 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SFN stratifin
SLC38A1 solute carrier family 38, member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
THSD7A thrombospondin, type I, domain containing 7A
TKTL1 transketolase-like 1
TSPAN12 tetraspanin 12
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XIST X inactive specific transcript (non-protein coding)
ZBTB20 zinc finger and BTB domain containing 20
ZNF551 zinc finger protein 551
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ADORA2B adenosine A2b receptor
AK1 adenylate kinase 1
BGN biglycan
CA2 carbonic anhydrase II
CDC20 cell division cycle 20
CTGF connective tissue growth factor
CTSH cathepsin H
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GSN gelsolin
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFRD2 interferon-related developmental regulator 2
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IVNS1ABP influenza virus NS1A binding protein
LTF lactotransferrin
LY6E lymphocyte antigen 6 complex, locus E
MDK midkine (neurite growth-promoting factor 2)
MET MET proto-oncogene, receptor tyrosine kinase
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
MYH10 myosin, heavy chain 10, non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
PDE4DIP phosphodiesterase 4D interacting protein
PFKP phosphofructokinase, platelet
PLD3 phospholipase D family, member 3
PLK2 polo-like kinase 2
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PTX3 pentraxin 3, long
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHB Src homology 2 domain containing adaptor protein B
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMCO4 single-pass membrane protein with coiled-coil domains 4
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
TTN titin
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
Funding