BRD-K16478699_PLX-4720_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K16478699_PLX-4720_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AQP1 aquaporin 1 (Colton blood group)
ASS1 argininosuccinate synthase 1
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C3 complement component 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNG1 cyclin G1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFH complement factor H
CLCA4 chloride channel accessory 4
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBRD1 cytochrome b reductase 1
DAPK1 death-associated protein kinase 1
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EFNA1 ephrin-A1
ELOVL5 ELOVL fatty acid elongase 5
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FKBP14 FK506 binding protein 14, 22 kDa
FSTL1 follistatin-like 1
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GSDMB gasdermin B
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HSPA2 heat shock 70kDa protein 2
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
ITM2C integral membrane protein 2C
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MAGED1 melanoma antigen family D1
MDFIC MyoD family inhibitor domain containing
MFAP5 microfibrillar associated protein 5
MVP major vault protein
OXTR oxytocin receptor
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PBX1 pre-B-cell leukemia homeobox 1
PDGFRL platelet-derived growth factor receptor-like
PIR pirin (iron-binding nuclear protein)
PLA2G16 phospholipase A2, group XVI
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PON2 paraoxonase 2
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL31 ribosomal protein L31
SCRG1 stimulator of chondrogenesis 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC22A18 solute carrier family 22, member 18
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX2 SRY (sex determining region Y)-box 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATA20 spermatogenesis associated 20
SPON2 spondin 2, extracellular matrix protein
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAGLN transgelin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM22 tripartite motif containing 22
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
AXIN1 axin 1
CAB39 calcium binding protein 39
CCL19 chemokine (C-C motif) ligand 19
CCND1 cyclin D1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CST6 cystatin E/M
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GTPBP4 GTP binding protein 4
HES1 hes family bHLH transcription factor 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
LEF1 lymphoid enhancer-binding factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1G metallothionein 1G
MT1X metallothionein 1X
NOLC1 nucleolar and coiled-body phosphoprotein 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
RAD51C RAD51 paralog C
S100P S100 calcium binding protein P
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STK10 serine/threonine kinase 10
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TCL1A T-cell leukemia/lymphoma 1A
TGFA transforming growth factor, alpha
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TRBC1 T cell receptor beta constant 1
VAT1 vesicle amine transport 1
Funding