BRD-K16478699_PLX-4720_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

239 genes differentially expressed following the BRD-K16478699_PLX-4720_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMACR alpha-methylacyl-CoA racemase
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAST calpastatin
CAT catalase
CCNG1 cyclin G1
CCNG2 cyclin G2
CD200 CD200 molecule
CD24 CD24 molecule
CD99 CD99 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFB complement factor B
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
CRYAB crystallin, alpha B
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DIAPH2 diaphanous-related formin 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DTX4 deltex 4, E3 ubiquitin ligase
EFHC1 EF-hand domain (C-terminal) containing 1
EFNA1 ephrin-A1
ELF1 E74-like factor 1 (ets domain transcription factor)
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPHX2 epoxide hydrolase 2, cytoplasmic
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FOLR1 folate receptor 1 (adult)
FOXO4 forkhead box O4
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GRAMD3 GRAM domain containing 3
GRN granulin
GSDMB gasdermin B
GSN gelsolin
HBP1 HMG-box transcription factor 1
HEPH hephaestin
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HMOX1 heme oxygenase 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LIMK2 LIM domain kinase 2
LOC100505650 uncharacterized LOC100505650
LXN latexin
LY75 lymphocyte antigen 75
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MLPH melanophilin
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NMI N-myc (and STAT) interactor
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLCB4 phospholipase C, beta 4
PROM1 prominin 1
PROS1 protein S (alpha)
PRR15L proline rich 15-like
PRUNE2 prune homolog 2 (Drosophila)
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRK protein tyrosine phosphatase, receptor type, K
QPRT quinolinate phosphoribosyltransferase
RAB13 RAB13, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SESN1 sestrin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC22A18 solute carrier family 22, member 18
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35E2B solute carrier family 35, member E2B
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC44A4 solute carrier family 44, member 4
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SP110 SP110 nuclear body protein
SSR4 signal sequence receptor, delta
TMC5 transmembrane channel-like 5
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPAN3 tetraspanin 3
TST thiosulfate sulfurtransferase (rhodanese)
USH1C Usher syndrome 1C (autosomal recessive, severe)
YPEL5 yippee-like 5 (Drosophila)
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BYSL bystin-like
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
ENOPH1 enolase-phosphatase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
FST follistatin
GINS2 GINS complex subunit 2 (Psf2 homolog)
HPRT1 hypoxanthine phosphoribosyltransferase 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
ITGA6 integrin, alpha 6
KIF20A kinesin family member 20A
LBR lamin B receptor
LMNB2 lamin B2
LOXL1 lysyl oxidase-like 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTF lactotransferrin
LYPLA1 lysophospholipase I
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTCL1 microtubule crosslinking factor 1
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
ODC1 ornithine decarboxylase 1
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PCDH9 protocadherin 9
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK1 polo-like kinase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
PRMT1 protein arginine methyltransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD23B RAD23 homolog B (S. cerevisiae)
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SRM spermidine synthase
STC2 stanniocalcin 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TRBC1 T cell receptor beta constant 1
TRIP13 thyroid hormone receptor interactor 13
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UPP1 uridine phosphorylase 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
Funding