BRD-K16485616_mocetinostat_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

205 genes differentially expressed following the BRD-K16485616_mocetinostat_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRG1 adhesion G protein-coupled receptor G1
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
ARG2 arginase 2
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
BST2 bone marrow stromal cell antigen 2
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSB cathepsin B
CYB5R1 cytochrome b5 reductase 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSTN destrin (actin depolymerizing factor)
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
EDNRB endothelin receptor type B
ENAH enabled homolog (Drosophila)
FABP4 fatty acid binding protein 4, adipocyte
FADS3 fatty acid desaturase 3
FBXO2 F-box protein 2
FERMT2 fermitin family member 2
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
FSD1 fibronectin type III and SPRY domain containing 1
FZD5 frizzled class receptor 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPR137B G protein-coupled receptor 137B
GSDMB gasdermin B
GSN gelsolin
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HK1 hexokinase 1
HN1 hematological and neurological expressed 1
HOOK2 hook microtubule-tethering protein 2
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INPP1 inositol polyphosphate-1-phosphatase
ISG15 ISG15 ubiquitin-like modifier
KIF5C kinesin family member 5C
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
KRT8 keratin 8, type II
L1CAM L1 cell adhesion molecule
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LPIN1 lipin 1
LSR lipolysis stimulated lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCAM melanoma cell adhesion molecule
MFAP3L microfibrillar-associated protein 3-like
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MT1X metallothionein 1X
MT2A metallothionein 2A
MX1 MX dynamin-like GTPase 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NLGN4X neuroligin 4, X-linked
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAT ornithine aminotransferase
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PALLD palladin, cytoskeletal associated protein
PAM peptidylglycine alpha-amidating monooxygenase
PDLIM1 PDZ and LIM domain 1
PLA2G15 phospholipase A2, group XV
PPAP2A phosphatidic acid phosphatase type 2A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB29 RAB29, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
RIMS3 regulating synaptic membrane exocytosis 3
RND3 Rho family GTPase 3
SAMD4A sterile alpha motif domain containing 4A
SARAF store-operated calcium entry-associated regulatory factor
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STOM stomatin
SYNGR3 synaptogyrin 3
TCEAL2 transcription elongation factor A (SII)-like 2
TES testin LIM domain protein
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMC6 transmembrane channel-like 6
TMEM2 transmembrane protein 2
TNC tenascin C
TPST2 tyrosylprotein sulfotransferase 2
TUBB2B tubulin, beta 2B class IIb
VCL vinculin
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADI1 acireductone dioxygenase 1
AGR2 anterior gradient 2
AKAP8 A kinase (PRKA) anchor protein 8
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASPN asporin
ATF5 activating transcription factor 5
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
COL6A1 collagen, type VI, alpha 1
CTBP1 C-terminal binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL2 ELOVL fatty acid elongase 2
EMP3 epithelial membrane protein 3
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLI2 GLI family zinc finger 2
GPR88 G protein-coupled receptor 88
GSTO1 glutathione S-transferase omega 1
HDDC2 HD domain containing 2
HDGF hepatoma-derived growth factor
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
HOXA5 homeobox A5
HP haptoglobin
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
JADE2 jade family PHD finger 2
KAT6B K(lysine) acetyltransferase 6B
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LRRC41 leucine rich repeat containing 41
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MOXD1 monooxygenase, DBH-like 1
MRPS30 mitochondrial ribosomal protein S30
MUC5B mucin 5B, oligomeric mucus/gel-forming
MZT2A mitotic spindle organizing protein 2A
MZT2B mitotic spindle organizing protein 2B
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OBSL1 obscurin-like 1
PAIP1 poly(A) binding protein interacting protein 1
PBK PDZ binding kinase
PHF11 PHD finger protein 11
PIP prolactin-induced protein
PMF1 polyamine-modulated factor 1
PPIF peptidylprolyl isomerase F
RAD51AP1 RAD51 associated protein 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
SENP6 SUMO1/sentrin specific peptidase 6
SHCBP1 SHC SH2-domain binding protein 1
SPAG7 sperm associated antigen 7
SPC25 SPC25, NDC80 kinetochore complex component
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TCF4 transcription factor 4
TFF1 trefoil factor 1
TP53 tumor protein p53
TSKU tsukushi, small leucine rich proteoglycan
VAV3 vav 3 guanine nucleotide exchange factor
ZBED1 zinc finger, BED-type containing 1
Funding