BRD-K16485616_mocetinostat_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K16485616_mocetinostat_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA10 annexin A10
BCL2 B-cell CLL/lymphoma 2
C3 complement component 3
CD14 CD14 molecule
CD163 CD163 molecule
CDK6 cyclin-dependent kinase 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLDN10 claudin 10
COL15A1 collagen, type XV, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
FRS2 fibroblast growth factor receptor substrate 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
HLA-DMA major histocompatibility complex, class II, DM alpha
HMOX1 heme oxygenase 1
IFI44L interferon-induced protein 44-like
IL1RAP interleukin 1 receptor accessory protein
ITM2C integral membrane protein 2C
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LEPROTL1 leptin receptor overlapping transcript-like 1
LMAN1 lectin, mannose-binding, 1
LPAR1 lysophosphatidic acid receptor 1
MAGEA3 melanoma antigen family A3
MCAM melanoma cell adhesion molecule
MEF2C myocyte enhancer factor 2C
MMP9 matrix metallopeptidase 9
MOCOS molybdenum cofactor sulfurase
MT1M metallothionein 1M
MUC5B mucin 5B, oligomeric mucus/gel-forming
OPHN1 oligophrenin 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS1 plastin 1
PLSCR4 phospholipid scramblase 4
PMP2 peripheral myelin protein 2
RELN reelin
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLPI secretory leukocyte peptidase inhibitor
SST somatostatin
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMP3 TIMP metallopeptidase inhibitor 3
TMPRSS4 transmembrane protease, serine 4
VNN1 vanin 1

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALOX15B arachidonate 15-lipoxygenase, type B
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C3ORF14 chromosome 3 open reading frame 14
CBR3 carbonyl reductase 3
CD81 CD81 molecule
CTBP1 C-terminal binding protein 1
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER5 immediate early response 5
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NLRP2 NLR family, pyrin domain containing 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLAGL1 pleiomorphic adenoma gene-like 1
S100A10 S100 calcium binding protein A10
SERHL2 serine hydrolase-like 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFB1 transforming growth factor, beta 1
TUBB2A tubulin, beta 2A class IIa
VDAC1 voltage-dependent anion channel 1
WNT5A wingless-type MMTV integration site family, member 5A
YME1L1 YME1-like 1 ATPase
Funding