BRD-K16485616_mocetinostat_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

234 genes differentially expressed following the BRD-K16485616_mocetinostat_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ABHD3 abhydrolase domain containing 3
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ACOT7 acyl-CoA thioesterase 7
ADA adenosine deaminase
ADGRG2 adhesion G protein-coupled receptor G2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
APOB apolipoprotein B
APOH apolipoprotein H (beta-2-glycoprotein I)
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C1ORF115 chromosome 1 open reading frame 115
C3 complement component 3
CA2 carbonic anhydrase II
CCNG2 cyclin G2
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CHGB chromogranin B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKLF chemokine-like factor
COL10A1 collagen, type X, alpha 1
CPD carboxypeptidase D
CTR9 CTR9, Paf1/RNA polymerase II complex component
CXADR coxsackie virus and adenovirus receptor
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
EAF2 ELL associated factor 2
EDNRB endothelin receptor type B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBLN1 fibulin 1
FGA fibrinogen alpha chain
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GRK5 G protein-coupled receptor kinase 5
GSTA1 glutathione S-transferase alpha 1
HAL histidine ammonia-lyase
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
INPP5F inositol polyphosphate-5-phosphatase F
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
JAG1 jagged 1
JARID2 jumonji, AT rich interactive domain 2
KIF5C kinesin family member 5C
KLHL24 kelch-like family member 24
LBH limb bud and heart development
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
METTL7A methyltransferase like 7A
MFAP4 microfibrillar-associated protein 4
MMD monocyte to macrophage differentiation-associated
MTUS1 microtubule associated tumor suppressor 1
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
OAT ornithine aminotransferase
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OPN3 opsin 3
ORM1 orosomucoid 1
OSBPL8 oxysterol binding protein-like 8
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB29 RAB29, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RIMS3 regulating synaptic membrane exocytosis 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTN2 reticulon 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGCE sarcoglycan, epsilon
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SKAP2 src kinase associated phosphoprotein 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
STOM stomatin
STX1A syntaxin 1A (brain)
STXBP1 syntaxin binding protein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCEA2 transcription elongation factor A (SII), 2
TFRC transferrin receptor
THBD thrombomodulin
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TNNT1 troponin T type 1 (skeletal, slow)
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TPST2 tyrosylprotein sulfotransferase 2
TSPAN7 tetraspanin 7
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
ZNF277 zinc finger protein 277
ZNF281 zinc finger protein 281
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADI1 acireductone dioxygenase 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARHGAP1 Rho GTPase activating protein 1
ATF5 activating transcription factor 5
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
AUTS2 autism susceptibility candidate 2
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALML5 calmodulin-like 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CEP55 centrosomal protein 55kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CNPY2 canopy FGF signaling regulator 2
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
DSG1 desmoglein 1
EFNB2 ephrin-B2
EFS embryonal Fyn-associated substrate
EGF epidermal growth factor
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKBP10 FK506 binding protein 10, 65 kDa
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
HDGF hepatoma-derived growth factor
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB6 homeobox B6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
LTF lactotransferrin
MOK MOK protein kinase
MT1M metallothionein 1M
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OXTR oxytocin receptor
PBK PDZ binding kinase
PLBD1 phospholipase B domain containing 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PPIF peptidylprolyl isomerase F
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RPL10 ribosomal protein L10
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCUBE2 signal peptide, CUB domain, EGF-like 2
SHCBP1 SHC SH2-domain binding protein 1
SORBS3 sorbin and SH3 domain containing 3
SPAG7 sperm associated antigen 7
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
WNT5A wingless-type MMTV integration site family, member 5A
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBED1 zinc finger, BED-type containing 1
ZIC1 Zic family member 1
ZMYND11 zinc finger, MYND-type containing 11
ZNF395 zinc finger protein 395
Funding