BRD-K16485616_mocetinostat_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K16485616_mocetinostat_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
APLP2 amyloid beta (A4) precursor-like protein 2
ATF3 activating transcription factor 3
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CSTB cystatin B (stefin B)
CTSL cathepsin L
DIAPH2 diaphanous-related formin 2
DPYSL2 dihydropyrimidinase-like 2
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO2 enolase 2 (gamma, neuronal)
FABP4 fatty acid binding protein 4, adipocyte
FKBP1B FK506 binding protein 1B, 12.6 kDa
FZD7 frizzled class receptor 7
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GPR137B G protein-coupled receptor 137B
HOMER1 homer scaffolding protein 1
HPCAL1 hippocalcin-like 1
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LGALS1 lectin, galactoside-binding, soluble, 1
LIPA lipase A, lysosomal acid, cholesterol esterase
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MFAP3L microfibrillar-associated protein 3-like
MOAP1 modulator of apoptosis 1
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
NDRG1 N-myc downstream regulated 1
OAT ornithine aminotransferase
OSBPL3 oxysterol binding protein-like 3
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PFKM phosphofructokinase, muscle
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
PMP22 peripheral myelin protein 22
PPARG peroxisome proliferator-activated receptor gamma
PRAF2 PRA1 domain family, member 2
PROM1 prominin 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SORD sorbitol dehydrogenase
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STC1 stanniocalcin 1
STXBP1 syntaxin binding protein 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNNT1 troponin T type 1 (skeletal, slow)
TRIB2 tribbles pseudokinase 2
TSC22D1 TSC22 domain family, member 1
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BARD1 BRCA1 associated RING domain 1
C8ORF4 chromosome 8 open reading frame 4
CBX5 chromobox homolog 5
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFB complement factor B
CLIC2 chloride intracellular channel 2
CLU clusterin
COBLL1 cordon-bleu WH2 repeat protein-like 1
DCLK1 doublecortin-like kinase 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLT1B golgi transport 1B
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H2AFX H2A histone family, member X
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
LMNB1 lamin B1
LTF lactotransferrin
LYZ lysozyme
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MT1F metallothionein 1F
PALMD palmdelphin
PCNA proliferating cell nuclear antigen
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRC1 protein regulator of cytokinesis 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM1 ribonucleotide reductase M1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TYMS thymidylate synthetase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP1 ubiquitin specific peptidase 1
ZBTB20 zinc finger and BTB domain containing 20
Funding