BRD-K16485616_mocetinostat_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K16485616_mocetinostat_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
BLVRA biliverdin reductase A
BTBD3 BTB (POZ) domain containing 3
CD24 CD24 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTBP2 C-terminal binding protein 2
CTSL cathepsin L
DAPK1 death-associated protein kinase 1
DNTT DNA nucleotidylexotransferase
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FOXO4 forkhead box O4
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HPCAL1 hippocalcin-like 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB1 heat shock 27kDa protein 1
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBB inhibin, beta B
ISG15 ISG15 ubiquitin-like modifier
KLF10 Kruppel-like factor 10
KRT7 keratin 7, type II
LGMN legumain
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MGAM maltase-glucoamylase
MICB MHC class I polypeptide-related sequence B
MID1 midline 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NQO1 NAD(P)H dehydrogenase, quinone 1
NREP neuronal regeneration related protein
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PRAME preferentially expressed antigen in melanoma
PRSS23 protease, serine, 23
PRTN3 proteinase 3
PRUNE2 prune homolog 2 (Drosophila)
PSPH phosphoserine phosphatase
RAB13 RAB13, member RAS oncogene family
RIMS3 regulating synaptic membrane exocytosis 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTN3 reticulon 3
SDC2 syndecan 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPTSSA serine palmitoyltransferase, small subunit A
STOM stomatin
STXBP1 syntaxin binding protein 1
SYT1 synaptotagmin I
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD86 CD86 molecule
COBLL1 cordon-bleu WH2 repeat protein-like 1
CST3 cystatin C
DCN decorin
DCTD dCMP deaminase
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
GATAD1 GATA zinc finger domain containing 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
JADE2 jade family PHD finger 2
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTF lactotransferrin
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MECOM MDS1 and EVI1 complex locus
MGP matrix Gla protein
MPZL2 myelin protein zero-like 2
MRPS30 mitochondrial ribosomal protein S30
MYCBP MYC binding protein
NCAPD3 non-SMC condensin II complex, subunit D3
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDLIM1 PDZ and LIM domain 1
PDZD2 PDZ domain containing 2
PLXNA2 plexin A2
POSTN periostin, osteoblast specific factor
QDPR quinoid dihydropteridine reductase
SASH1 SAM and SH3 domain containing 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35F2 solute carrier family 35, member F2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
SPRR3 small proline-rich protein 3
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
THBD thrombomodulin
THY1 Thy-1 cell surface antigen
TMEM30B transmembrane protein 30B
TMEM5 transmembrane protein 5
TRIM29 tripartite motif containing 29
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
Funding