BRD-K16485616_mocetinostat_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-K16485616_mocetinostat_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTN1 actinin, alpha 1
ADGRF5 adhesion G protein-coupled receptor F5
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ARG2 arginase 2
ATRX alpha thalassemia/mental retardation syndrome X-linked
BLMH bleomycin hydrolase
BLVRA biliverdin reductase A
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD36 CD36 molecule (thrombospondin receptor)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL5A2 collagen, type V, alpha 2
CREBL2 cAMP responsive element binding protein-like 2
CREG1 cellular repressor of E1A-stimulated genes 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSB cathepsin B
CTSL cathepsin L
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DEGS1 delta(4)-desaturase, sphingolipid 1
DPYSL2 dihydropyrimidinase-like 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENAH enabled homolog (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAM49A family with sequence similarity 49, member A
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNB5 guanine nucleotide binding protein (G protein), beta 5
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
GPR161 G protein-coupled receptor 161
GREM1 gremlin 1, DAN family BMP antagonist
GYG2 glycogenin 2
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HPCAL1 hippocalcin-like 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP7 insulin-like growth factor binding protein 7
KYNU kynureninase
LGMN legumain
LMO2 LIM domain only 2 (rhombotin-like 1)
LOXL2 lysyl oxidase-like 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOA monoamine oxidase A
METRN meteorin, glial cell differentiation regulator
MID1 midline 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MMP9 matrix metallopeptidase 9
MT1X metallothionein 1X
MT2A metallothionein 2A
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPTX2 neuronal pentraxin II
NRN1 neuritin 1
NRP1 neuropilin 1
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OSTM1 osteopetrosis associated transmembrane protein 1
PALLD palladin, cytoskeletal associated protein
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM3 PDZ and LIM domain 3
PFKM phosphofructokinase, muscle
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PMP22 peripheral myelin protein 22
PODXL podocalyxin-like
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
RAB26 RAB26, member RAS oncogene family
RAB29 RAB29, member RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
RIMS3 regulating synaptic membrane exocytosis 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SCPEP1 serine carboxypeptidase 1
SDC2 syndecan 2
SDCBP syndecan binding protein (syntenin)
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMYD3 SET and MYND domain containing 3
SNAI2 snail family zinc finger 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
STOM stomatin
STXBP1 syntaxin binding protein 1
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
SYT17 synaptotagmin XVII
TBPL1 TBP-like 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM123 transmembrane protein 123
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TRIM2 tripartite motif containing 2
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TXNRD1 thioredoxin reductase 1
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
AKR1C2 aldo-keto reductase family 1, member C2
CCNA2 cyclin A2
CRYAB crystallin, alpha B
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYTIP cytohesin 1 interacting protein
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPT dermatopontin
DUSP5 dual specificity phosphatase 5
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
FAM57A family with sequence similarity 57, member A
FERMT1 fermitin family member 1
GAS2 growth arrest-specific 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRWD1 glutamate-rich WD repeat containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGHM immunoglobulin heavy constant mu
KIAA0101 KIAA0101
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK6 kallikrein-related peptidase 6
KRT13 keratin 13, type I
KRT7 keratin 7, type II
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MAL mal, T-cell differentiation protein
MAPK13 mitogen-activated protein kinase 13
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MRPS30 mitochondrial ribosomal protein S30
MYRF myelin regulatory factor
NAT10 N-acetyltransferase 10 (GCN5-related)
PDLIM1 PDZ and LIM domain 1
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PMP2 peripheral myelin protein 2
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRMT1 protein arginine methyltransferase 1
PSCA prostate stem cell antigen
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMG2 proteasome (prosome, macropain) assembly chaperone 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
PXMP2 peroxisomal membrane protein 2, 22kDa
SCEL sciellin
SIAH2 siah E3 ubiquitin protein ligase 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TCL1A T-cell leukemia/lymphoma 1A
TJP2 tight junction protein 2
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TYMS thymidylate synthetase
U2SURP U2 snRNP-associated SURP domain containing
UBE2C ubiquitin-conjugating enzyme E2C
UPK1B uroplakin 1B
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
ZNF586 zinc finger protein 586
Funding