BRD-K16485616_mocetinostat_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

173 genes differentially expressed following the BRD-K16485616_mocetinostat_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADA adenosine deaminase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOC aldolase C, fructose-bisphosphate
ANXA1 annexin A1
ASPH aspartate beta-hydroxylase
CD59 CD59 molecule, complement regulatory protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGRRF1 cell growth regulator with ring finger domain 1
CLEC2B C-type lectin domain family 2, member B
CTSL cathepsin L
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DMBT1 deleted in malignant brain tumors 1
DUOX2 dual oxidase 2
ECM1 extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP1 fatty acid binding protein 1, liver
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FERMT2 fermitin family member 2
FOXO4 forkhead box O4
FSTL1 follistatin-like 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTA4 glutathione S-transferase alpha 4
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP1 insulin-like growth factor binding protein 1
ISG15 ISG15 ubiquitin-like modifier
ITGA6 integrin, alpha 6
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KRT20 keratin 20, type I
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
LPIN1 lipin 1
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP2 microfibrillar-associated protein 2
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
PALLD palladin, cytoskeletal associated protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKM phosphofructokinase, muscle
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLIN2 perilipin 2
POR P450 (cytochrome) oxidoreductase
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROM1 prominin 1
PRSS3 protease, serine, 3
RBP4 retinol binding protein 4, plasma
REG3A regenerating islet-derived 3 alpha
RHOBTB3 Rho-related BTB domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RUNX1 runt-related transcription factor 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SFXN3 sideroflexin 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
STOM stomatin
STXBP1 syntaxin binding protein 1
SYNGR3 synaptogyrin 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TMCO3 transmembrane and coiled-coil domains 3
TMEM2 transmembrane protein 2
TRAK2 trafficking protein, kinesin binding 2
TXNRD1 thioredoxin reductase 1
VIM vimentin
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
WLS wntless Wnt ligand secretion mediator
XK X-linked Kx blood group

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANAPC5 anaphase promoting complex subunit 5
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE41 basic helix-loop-helix family, member e41
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
C1QBP complement component 1, q subcomponent binding protein
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHL1 cell adhesion molecule L1-like
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRYAB crystallin, alpha B
DCK deoxycytidine kinase
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DUT deoxyuridine triphosphatase
ESR1 estrogen receptor 1
FGFR3 fibroblast growth factor receptor 3
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GATA3 GATA binding protein 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPR183 G protein-coupled receptor 183
GRWD1 glutamate-rich WD repeat containing 1
HCAR3 hydroxycarboxylic acid receptor 3
ICAM3 intercellular adhesion molecule 3
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MREG melanoregulin
MSLN mesothelin
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRR7 proline rich 7 (synaptic)
RFC3 replication factor C (activator 1) 3, 38kDa
RGS1 regulator of G-protein signaling 1
RRM1 ribonucleotide reductase M1
SLIT2 slit homolog 2 (Drosophila)
SPON2 spondin 2, extracellular matrix protein
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
THAP11 THAP domain containing 11
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TRAPPC2L trafficking protein particle complex 2-like
UBE2C ubiquitin-conjugating enzyme E2C
Funding