BRD-K16485616_mocetinostat_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K16485616_mocetinostat_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA1 annexin A1
APOD apolipoprotein D
BASP1 brain abundant, membrane attached signal protein 1
BMP2 bone morphogenetic protein 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLDN3 claudin 3
CLDN7 claudin 7
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DEFB1 defensin, beta 1
DUSP6 dual specificity phosphatase 6
ENO2 enolase 2 (gamma, neuronal)
EXOSC4 exosome component 4
FADS1 fatty acid desaturase 1
FOXO1 forkhead box O1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT6B keratin 6B, type II
KRT8 keratin 8, type II
LAMC2 laminin, gamma 2
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MAL mal, T-cell differentiation protein
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MFAP2 microfibrillar-associated protein 2
MLF1 myeloid leukemia factor 1
MLPH melanophilin
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RNASE4 ribonuclease, RNase A family, 4
SCGB2A1 secretoglobin, family 2A, member 1
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC43A3 solute carrier family 43, member 3
SOD2 superoxide dismutase 2, mitochondrial
STC1 stanniocalcin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THEMIS2 thymocyte selection associated family member 2
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATMIN ATM interactor
AUTS2 autism susceptibility candidate 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHMP4A charged multivesicular body protein 4A
COL3A1 collagen, type III, alpha 1
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FKBP11 FK506 binding protein 11, 19 kDa
GLI2 GLI family zinc finger 2
GPX2 glutathione peroxidase 2
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
NEFL neurofilament, light polypeptide
NPTX2 neuronal pentraxin II
NTS neurotensin
OLFM4 olfactomedin 4
PTCH1 patched 1
PYCARD PYD and CARD domain containing
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SHCBP1 SHC SH2-domain binding protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX9 SRY (sex determining region Y)-box 9
SPARCL1 SPARC-like 1 (hevin)
STK39 serine threonine kinase 39
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
Funding