BRD-K17023947_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K17023947_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CAPG capping protein (actin filament), gelsolin-like
CD24 CD24 molecule
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EREG epiregulin
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
HILPDA hypoxia inducible lipid droplet-associated
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IL6 interleukin 6
INHBA inhibin, beta A
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
KRT20 keratin 20, type I
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NNMT nicotinamide N-methyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PRSS3 protease, serine, 3
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMAGP small cell adhesion glycoprotein
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
VEGFC vascular endothelial growth factor C
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ANKRD10 ankyrin repeat domain 10
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
FRZB frizzled-related protein
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HACD3 3-hydroxyacyl-CoA dehydratase 3
IGKV1-5 immunoglobulin kappa variable 1-5
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
LMO3 LIM domain only 3 (rhombotin-like 2)
MUC16 mucin 16, cell surface associated
PTPRO protein tyrosine phosphatase, receptor type, O
SERINC5 serine incorporator 5
TRIB2 tribbles pseudokinase 2
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