BRD-K17140735_-666_HEPG2_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K17140735_-666_HEPG2_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BHLHE40 basic helix-loop-helix family, member e40
BRD4 bromodomain containing 4
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CLEC2B C-type lectin domain family 2, member B
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR2 early growth response 2
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM69A family with sequence similarity 69, member A
FGFBP1 fibroblast growth factor binding protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GRB7 growth factor receptor-bound protein 7
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS2 Meis homeobox 2
MT1G metallothionein 1G
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
MYO15B myosin XVB
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
PER1 period circadian clock 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RSAD2 radical S-adenosyl methionine domain containing 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHB Src homology 2 domain containing adaptor protein B
SQLE squalene epoxidase
ST18 suppression of tumorigenicity 18, zinc finger
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TPM2 tropomyosin 2 (beta)
TRIB1 tribbles pseudokinase 1
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
XAF1 XIAP associated factor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CCNA2 cyclin A2
CCNG1 cyclin G1
CD59 CD59 molecule, complement regulatory protein
CDK1 cyclin-dependent kinase 1
CLIC4 chloride intracellular channel 4
CLU clusterin
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF5A eukaryotic translation initiation factor 5A
FADS1 fatty acid desaturase 1
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
HP haptoglobin
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARCKSL1 MARCKS-like 1
MEF2C myocyte enhancer factor 2C
MYH10 myosin, heavy chain 10, non-muscle
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFM1 olfactomedin 1
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PSAT1 phosphoserine aminotransferase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
REEP1 receptor accessory protein 1
S100P S100 calcium binding protein P
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
STOM stomatin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM47 transmembrane protein 47
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