BRD-K17140735_-666_MCF7_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

199 genes differentially expressed following the BRD-K17140735_-666_MCF7_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID1A AT rich interactive domain 1A (SWI-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATXN1 ataxin 1
BHLHE40 basic helix-loop-helix family, member e40
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD44 CD44 molecule (Indian blood group)
CLDN3 claudin 3
CLDN4 claudin 4
COG5 component of oligomeric golgi complex 5
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP8 dual specificity phosphatase 8
EGR1 early growth response 1
FAM129A family with sequence similarity 129, member A
FAM60A family with sequence similarity 60, member A
FASN fatty acid synthase
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL6 interleukin 6
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT6B keratin 6B, type II
KYNU kynureninase
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LPP LIM domain containing preferred translocation partner in lipoma
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
NBPF10 neuroblastoma breakpoint family, member 10
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NKX3-1 NK3 homeobox 1
NRIP1 nuclear receptor interacting protein 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDM1 PR domain containing 1, with ZNF domain
PXN paxillin
RAD23A RAD23 homolog A (S. cerevisiae)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIPK2 receptor-interacting serine-threonine kinase 2
RNF19B ring finger protein 19B
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SETD5 SET domain containing 5
SHB Src homology 2 domain containing adaptor protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SQSTM1 sequestosome 1
STX3 syntaxin 3
SYNGR3 synaptogyrin 3
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TLK2 tousled-like kinase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRAF1 TNF receptor-associated factor 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UBE2H ubiquitin-conjugating enzyme E2H
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WAC WW domain containing adaptor with coiled-coil
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZYX zyxin

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ANPEP alanyl (membrane) aminopeptidase
ASCL1 achaete-scute family bHLH transcription factor 1
ATF5 activating transcription factor 5
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
B3GNT1
BAG3 BCL2-associated athanogene 3
CASP6 caspase 6, apoptosis-related cysteine peptidase
CDC25A cell division cycle 25A
COX11 COX11 cytochrome c oxidase copper chaperone
COX5B cytochrome c oxidase subunit Vb
COX7B cytochrome c oxidase subunit VIIb
CYCS cytochrome c, somatic
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6B glycoprotein M6B
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGN3 high mobility group nucleosomal binding domain 3
HOXC6 homeobox C6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTBP1 latent transforming growth factor beta binding protein 1
MAT2A methionine adenosyltransferase II, alpha
MGST3 microsomal glutathione S-transferase 3
MT1M metallothionein 1M
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NDUFA4 NDUFA4, mitochondrial complex associated
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
OIP5 Opa interacting protein 5
OLFM4 olfactomedin 4
OLFML3 olfactomedin-like 3
PEX11A peroxisomal biogenesis factor 11 alpha
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPS27L ribosomal protein S27-like
SEPW1 selenoprotein W, 1
SFPQ splicing factor proline/glutamine-rich
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNRPG small nuclear ribonucleoprotein polypeptide G
SPINK1 serine peptidase inhibitor, Kazal type 1
SRGN serglycin
SYNM synemin, intermediate filament protein
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM47 transmembrane protein 47
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TXNL4A thioredoxin-like 4A
WFS1 Wolfram syndrome 1 (wolframin)
WRB tryptophan rich basic protein