BRD-K17497770_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K17497770_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANK2 ankyrin 2, neuronal
ASS1 argininosuccinate synthase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBS cystathionine-beta-synthase
CCR1 chemokine (C-C motif) receptor 1
CD14 CD14 molecule
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL9A2 collagen, type IX, alpha 2
CTSL cathepsin L
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EMX2 empty spiracles homeobox 2
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KEAP1 kelch-like ECH-associated protein 1
MAOB monoamine oxidase B
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
NBPF10 neuroblastoma breakpoint family, member 10
NDRG1 N-myc downstream regulated 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PDGFA platelet-derived growth factor alpha polypeptide
PPAP2B phosphatidic acid phosphatase type 2B
PSAP prosaposin
SAMD4A sterile alpha motif domain containing 4A
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SQSTM1 sequestosome 1
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CKS2 CDC28 protein kinase regulatory subunit 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FXYD3 FXYD domain containing ion transport regulator 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
KRT18 keratin 18, type I
LPL lipoprotein lipase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
QDPR quinoid dihydropteridine reductase
SKAP2 src kinase associated phosphoprotein 2
SOX11 SRY (sex determining region Y)-box 11
SRSF6 serine/arginine-rich splicing factor 6
STOM stomatin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TSPAN13 tetraspanin 13
UGCG UDP-glucose ceramide glucosyltransferase
Funding