BRD-K17743125_belinostat_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

269 genes differentially expressed following the BRD-K17743125_belinostat_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACKR3 atypical chemokine receptor 3
ACPP acid phosphatase, prostate
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDOA aldolase A, fructose-bisphosphate
ARHGAP29 Rho GTPase activating protein 29
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAMBI BMP and activin membrane-bound inhibitor
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
C2CD2L C2CD2-like
C8ORF4 chromosome 8 open reading frame 4
C9ORF3 chromosome 9 open reading frame 3
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAV2 caveolin 2
CBR1 carbonyl reductase 1
CCDC85B coiled-coil domain containing 85B
CCL20 chemokine (C-C motif) ligand 20
CCND3 cyclin D3
CD24 CD24 molecule
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CLCA1 chloride channel accessory 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CYBB cytochrome b-245, beta polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DHCR7 7-dehydrocholesterol reductase
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DSTN destrin (actin depolymerizing factor)
DUSP10 dual specificity phosphatase 10
EDNRB endothelin receptor type B
EFNB2 ephrin-B2
FABP1 fatty acid binding protein 1, liver
FAM117A family with sequence similarity 117, member A
FGF13 fibroblast growth factor 13
FOXO4 forkhead box O4
G0S2 G0/G1 switch 2
G6PD glucose-6-phosphate dehydrogenase
GAGE3 G antigen 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLIPR1 GLI pathogenesis-related 1
GPX3 glutathione peroxidase 3
GRN granulin
GSDMB gasdermin B
HBEGF heparin-binding EGF-like growth factor
HIST1H3H histone cluster 1, H3h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPCAL1 hippocalcin-like 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
JARID2 jumonji, AT rich interactive domain 2
JUN jun proto-oncogene
JUND jun D proto-oncogene
LEPROTL1 leptin receptor overlapping transcript-like 1
LGMN legumain
LIPG lipase, endothelial
LPL lipoprotein lipase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MCAM melanoma cell adhesion molecule
MEGF9 multiple EGF-like-domains 9
MIR22HG MIR22 host gene
MMP3 matrix metallopeptidase 3
MX1 MX dynamin-like GTPase 1
NCAM1 neural cell adhesion molecule 1
NDNF neuron-derived neurotrophic factor
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELFE negative elongation factor complex member E
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NOSIP nitric oxide synthase interacting protein
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRCAM neuronal cell adhesion molecule
OLFM4 olfactomedin 4
OSTM1 osteopetrosis associated transmembrane protein 1
PALLD palladin, cytoskeletal associated protein
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PELO pelota homolog (Drosophila)
PLA2G15 phospholipase A2, group XV
PLK2 polo-like kinase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PSAP prosaposin
RCAN1 regulator of calcineurin 1
REG1A regenerating islet-derived 1 alpha
REG1B regenerating islet-derived 1 beta
REG3A regenerating islet-derived 3 alpha
RHOB ras homolog family member B
SC5D sterol-C5-desaturase
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2D1A SH2 domain containing 1A
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTSSA serine palmitoyltransferase, small subunit A
SSBP2 single-stranded DNA binding protein 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TMSB15A thymosin beta 15a
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1
WRB tryptophan rich basic protein
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ABR active BCR-related
ACSL5 acyl-CoA synthetase long-chain family member 5
ADI1 acireductone dioxygenase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
ANXA1 annexin A1
CBR3 carbonyl reductase 3
CCNB2 cyclin B2
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CIRBP cold inducible RNA binding protein
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COMT catechol-O-methyltransferase
COPS7A COP9 signalosome subunit 7A
CRTAP cartilage associated protein
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCTD dCMP deaminase
ELANE elastase, neutrophil expressed
EPCAM epithelial cell adhesion molecule
EPN2 epsin 2
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FMOD fibromodulin
FOXM1 forkhead box M1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GOLM1 golgi membrane protein 1
GPATCH8 G patch domain containing 8
HDDC2 HD domain containing 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMGA2 high mobility group AT-hook 2
HOMER3 homer scaffolding protein 3
HOXB2 homeobox B2
HOXB7 homeobox B7
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPB1 heat shock 27kDa protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT5 keratin 5, type II
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK13 mitogen-activated protein kinase 13
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MICALL1 MICAL-like 1
MLPH melanophilin
MPDU1 mannose-P-dolichol utilization defect 1
MPO myeloperoxidase
MSRA methionine sulfoxide reductase A
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYOF myoferlin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NNT nicotinamide nucleotide transhydrogenase
NT5E 5'-nucleotidase, ecto (CD73)
NUP62 nucleoporin 62kDa
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCNA proliferating cell nuclear antigen
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAU plasminogen activator, urokinase
PMP22 peripheral myelin protein 22
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPAP2C phosphatidic acid phosphatase type 2C
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB25 RAB25, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNH1 ribonuclease/angiogenin inhibitor 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3YL1 SH3 and SYLF domain containing 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35F2 solute carrier family 35, member F2
SORBS3 sorbin and SH3 domain containing 3
SPAG4 sperm associated antigen 4
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFDP1 transcription factor Dp-1
TMEM5 transmembrane protein 5
TMF1 TATA element modulatory factor 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UFC1 ubiquitin-fold modifier conjugating enzyme 1
ULK2 unc-51 like autophagy activating kinase 2
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
USP22 ubiquitin specific peptidase 22
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF264 zinc finger protein 264
ZWINT ZW10 interacting kinetochore protein
Funding