BRD-K17953061_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

194 genes differentially expressed following the BRD-K17953061_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
C3ORF14 chromosome 3 open reading frame 14
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN2 chimerin 2
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COLEC12 collectin sub-family member 12
CRELD2 cysteine-rich with EGF-like domains 2
CTSS cathepsin S
DCHS1 dachsous cadherin-related 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ETHE1 ethylmalonic encephalopathy 1
EVI2A ecotropic viral integration site 2A
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HDGFRP3 hepatoma-derived growth factor, related protein 3
HOMER2 homer scaffolding protein 2
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LCN2 lipocalin 2
LRRC17 leucine rich repeat containing 17
MDFIC MyoD family inhibitor domain containing
MEIS1 Meis homeobox 1
MXRA5 matrix-remodelling associated 5
NLGN4X neuroligin 4, X-linked
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PFKM phosphofructokinase, muscle
PLAU plasminogen activator, urokinase
PPL periplakin
PPT1 palmitoyl-protein thioesterase 1
PRDX2 peroxiredoxin 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PYCARD PYD and CARD domain containing
RGS10 regulator of G-protein signaling 10
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SFRP1 secreted frizzled-related protein 1
SOCS2 suppressor of cytokine signaling 2
SSPN sarcospan
SST somatostatin
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
TCF4 transcription factor 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPBG trophoblast glycoprotein
TRIB2 tribbles pseudokinase 2
TRIL TLR4 interactor with leucine-rich repeats
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WLS wntless Wnt ligand secretion mediator
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADGRG6 adhesion G protein-coupled receptor G6
AFG3L2 AFG3-like AAA ATPase 2
AKAP12 A kinase (PRKA) anchor protein 12
AMD1 adenosylmethionine decarboxylase 1
AMDHD2 amidohydrolase domain containing 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BST2 bone marrow stromal cell antigen 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL19 chemokine (C-C motif) ligand 19
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CHERP calcium homeostasis endoplasmic reticulum protein
CHMP4A charged multivesicular body protein 4A
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHPT1 choline phosphotransferase 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO1 deiodinase, iodothyronine, type I
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP6 dual specificity phosphatase 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELF1 E74-like factor 1 (ets domain transcription factor)
F5 coagulation factor V (proaccelerin, labile factor)
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FLNB filamin B, beta
FOSL1 FOS-like antigen 1
GCH1 GTP cyclohydrolase 1
GLS glutaminase
GNAS GNAS complex locus
GRWD1 glutamate-rich WD repeat containing 1
GSPT1 G1 to S phase transition 1
GSPT2 G1 to S phase transition 2
GTPBP4 GTP binding protein 4
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JMJD6 jumonji domain containing 6
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LPP LIM domain containing preferred translocation partner in lipoma
MALL mal, T-cell differentiation protein-like
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MRPS30 mitochondrial ribosomal protein S30
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
PFKP phosphofructokinase, platelet
PLAC8 placenta-specific 8
PLAGL2 pleiomorphic adenoma gene-like 2
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PPIF peptidylprolyl isomerase F
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RHOB ras homolog family member B
RNF6 ring finger protein (C3H2C3 type) 6
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
S100P S100 calcium binding protein P
SCAF8 SR-related CTD-associated factor 8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMAD7 SMAD family member 7
SMCO4 single-pass membrane protein with coiled-coil domains 4
SOX4 SRY (sex determining region Y)-box 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STK26 serine/threonine protein kinase 26
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBP TATA box binding protein
TFB2M transcription factor B2, mitochondrial
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TXLNA taxilin alpha
UBE3C ubiquitin protein ligase E3C
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
Funding