BRD-K18163752_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K18163752_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF6 activating transcription factor 6
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFB complement factor B
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
COL8A2 collagen, type VIII, alpha 2
COMP cartilage oligomeric matrix protein
CTSK cathepsin K
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
ELOVL5 ELOVL fatty acid elongase 5
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPRS glutamyl-prolyl-tRNA synthetase
FTH1 ferritin, heavy polypeptide 1
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ISG20 interferon stimulated exonuclease gene 20kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
KIF14 kinesin family member 14
KLF2 Kruppel-like factor 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRL platelet-derived growth factor receptor-like
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
S100A8 S100 calcium binding protein A8
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC38A1 solute carrier family 38, member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
TARS threonyl-tRNA synthetase
TRBC1 T cell receptor beta constant 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
B3GNT1
BAD BCL2-associated agonist of cell death
BHLHE41 basic helix-loop-helix family, member e41
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CIAPIN1 cytokine induced apoptosis inhibitor 1
COPS7A COP9 signalosome subunit 7A
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
KRT13 keratin 13, type I
NDP Norrie disease (pseudoglioma)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRSS23 protease, serine, 23
PVALB parvalbumin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SPINK1 serine peptidase inhibitor, Kazal type 1
TFPI2 tissue factor pathway inhibitor 2
TMEM100 transmembrane protein 100