BRD-K18724229_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-K18724229_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL2 adhesion G protein-coupled receptor L2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANOS1 anosmin 1
API5 apoptosis inhibitor 5
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARG2 arginase 2
ATF3 activating transcription factor 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BASP1 brain abundant, membrane attached signal protein 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BMP7 bone morphogenetic protein 7
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
CAB39 calcium binding protein 39
CCP110 centriolar coiled coil protein 110kDa
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CKM creatine kinase, muscle
CLIC5 chloride intracellular channel 5
COCH cochlin
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CPM carboxypeptidase M
CRISP3 cysteine-rich secretory protein 3
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSRP2 cysteine and glycine-rich protein 2
CXCL9 chemokine (C-X-C motif) ligand 9
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAS Fas cell surface death receptor
FGFR3 fibroblast growth factor receptor 3
FHOD3 formin homology 2 domain containing 3
FOSL1 FOS-like antigen 1
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GMPR guanosine monophosphate reductase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLM1 golgi membrane protein 1
GRN granulin
H3F3B H3 histone, family 3B (H3.3B)
HECA headcase homolog (Drosophila)
HEG1 heart development protein with EGF-like domains 1
HOPX HOP homeobox
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER5 immediate early response 5
IFT57 intraflagellar transport 57
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KAT6A K(lysine) acetyltransferase 6A
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LAMP3 lysosomal-associated membrane protein 3
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNA lamin A/C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MARK4 MAP/microtubule affinity-regulating kinase 4
MOSPD1 motile sperm domain containing 1
MYO6 myosin VI
P3H2 prolyl 3-hydroxylase 2
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RAB7A RAB7A, member RAS oncogene family
RAD51C RAD51 paralog C
RALGDS ral guanine nucleotide dissociation stimulator
RBM8A RNA binding motif protein 8A
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF19B ring finger protein 19B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STON1 stonin 1
STX3 syntaxin 3
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TPM4 tropomyosin 4
TSPAN12 tetraspanin 12
TXNIP thioredoxin interacting protein
UBE3B ubiquitin protein ligase E3B
WLS wntless Wnt ligand secretion mediator
YBX3 Y box binding protein 3
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC11 zinc finger, DHHC-type containing 11
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
ANXA10 annexin A10
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCNA2 cyclin A2
CCNF cyclin F
CD200 CD200 molecule
CD58 CD58 molecule
CDCA4 cell division cycle associated 4
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CHMP6 charged multivesicular body protein 6
COL14A1 collagen, type XIV, alpha 1
COL16A1 collagen, type XVI, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF3G eukaryotic translation initiation factor 3, subunit G
EIF3K eukaryotic translation initiation factor 3, subunit K
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
FCGBP Fc fragment of IgG binding protein
FKBP14 FK506 binding protein 14, 22 kDa
FXYD5 FXYD domain containing ion transport regulator 5
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPM6B glycoprotein M6B
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IFI44L interferon-induced protein 44-like
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
JARID2 jumonji, AT rich interactive domain 2
KLHL9 kelch-like family member 9
KYNU kynureninase
LYZ lysozyme
MAN1C1 mannosidase, alpha, class 1C, member 1
MAT2A methionine adenosyltransferase II, alpha
MED13L mediator complex subunit 13-like
MSX1 msh homeobox 1
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOV nephroblastoma overexpressed
NPM3 nucleophosmin/nucleoplasmin 3
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAM peptidylglycine alpha-amidating monooxygenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PON2 paraoxonase 2
PROM1 prominin 1
PRR15L proline rich 15-like
RBM28 RNA binding motif protein 28
RELN reelin
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNASE4 ribonuclease, RNase A family, 4
RPP40 ribonuclease P/MRP 40kDa subunit
S100A6 S100 calcium binding protein A6
SCAND1 SCAN domain containing 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SOD2 superoxide dismutase 2, mitochondrial
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFB3 transforming growth factor, beta 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNPO1 transportin 1
TSC22D1 TSC22 domain family, member 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
XBP1 X-box binding protein 1
ZNF652 zinc finger protein 652
Funding