BRD-K18787491_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K18787491_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHN2 chimerin 2
COL1A2 collagen, type I, alpha 2
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
EML3 echinoderm microtubule associated protein like 3
EXT1 exostosin glycosyltransferase 1
FABP4 fatty acid binding protein 4, adipocyte
FAM117A family with sequence similarity 117, member A
FAM63A family with sequence similarity 63, member A
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HBD hemoglobin, delta
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IFI30 interferon, gamma-inducible protein 30
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISYNA1 inositol-3-phosphate synthase 1
KLF4 Kruppel-like factor 4 (gut)
LMO2 LIM domain only 2 (rhombotin-like 1)
LTBP2 latent transforming growth factor beta binding protein 2
LTF lactotransferrin
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MT1M metallothionein 1M
MT1X metallothionein 1X
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PIR pirin (iron-binding nuclear protein)
PLXND1 plexin D1
PSAP prosaposin
PTK2 protein tyrosine kinase 2
RGS1 regulator of G-protein signaling 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BP4 SH3-domain binding protein 4
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAT1 signal transducer and activator of transcription 1, 91kDa
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKT transketolase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
CALB1 calbindin 1, 28kDa
CD24 CD24 molecule
CDC42 cell division cycle 42
CNPY3 canopy FGF signaling regulator 3
CTSG cathepsin G
DPT dermatopontin
DUSP4 dual specificity phosphatase 4
EPCAM epithelial cell adhesion molecule
FAIM Fas apoptotic inhibitory molecule
FOSL1 FOS-like antigen 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IER3 immediate early response 3
LPL lipoprotein lipase
NFIB nuclear factor I/B
PAPD7 PAP associated domain containing 7
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRNP prion protein
PRSS23 protease, serine, 23
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
TACSTD2 tumor-associated calcium signal transducer 2
TBX2 T-box 2
TIMP3 TIMP metallopeptidase inhibitor 3
TUSC3 tumor suppressor candidate 3
XBP1 X-box binding protein 1
Funding