BRD-K18861610_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K18861610_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
CAPG capping protein (actin filament), gelsolin-like
CBS cystathionine-beta-synthase
CD47 CD47 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKAP4 cytoskeleton-associated protein 4
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYAB crystallin, alpha B
DIXDC1 DIX domain containing 1
DUSP5 dual specificity phosphatase 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENO2 enolase 2 (gamma, neuronal)
FLOT1 flotillin 1
IER3 immediate early response 3
IRS1 insulin receptor substrate 1
KANK1 KN motif and ankyrin repeat domains 1
LAPTM4B lysosomal protein transmembrane 4 beta
LTA4H leukotriene A4 hydrolase
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MTA1 metastasis associated 1
MTMR11 myotubularin related protein 11
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NYNRIN NYN domain and retroviral integrase containing
OXTR oxytocin receptor
PAPOLA poly(A) polymerase alpha
PLBD1 phospholipase B domain containing 1
PLCB4 phospholipase C, beta 4
RRBP1 ribosome binding protein 1
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFN stratifin
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SORBS1 sorbin and SH3 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST5 suppression of tumorigenicity 5
TM7SF2 transmembrane 7 superfamily member 2
TRIP6 thyroid hormone receptor interactor 6

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANXA10 annexin A10
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATF5 activating transcription factor 5
BGN biglycan
CD40 CD40 molecule, TNF receptor superfamily member 5
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DPP4 dipeptidyl-peptidase 4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
EVI2A ecotropic viral integration site 2A
FASTKD5 FAST kinase domains 5
FGFR2 fibroblast growth factor receptor 2
FRZB frizzled-related protein
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPM6B glycoprotein M6B
GREM1 gremlin 1, DAN family BMP antagonist
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IL13RA2 interleukin 13 receptor, alpha 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
MAN1A1 mannosidase, alpha, class 1A, member 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX2 peroxiredoxin 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN1 reticulon 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAI2 snail family zinc finger 2
SPINK1 serine peptidase inhibitor, Kazal type 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TAC1 tachykinin, precursor 1
TMEM47 transmembrane protein 47
ZFP36L2 ZFP36 ring finger protein-like 2
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