BRD-K19136521_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K19136521_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALB albumin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGAP29 Rho GTPase activating protein 29
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLU clusterin
CPB1 carboxypeptidase B1 (tissue)
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
FAM129A family with sequence similarity 129, member A
GDF15 growth differentiation factor 15
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
LOR loricrin
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRNP prion protein
PRSS2 protease, serine, 2 (trypsin 2)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PTPRO protein tyrosine phosphatase, receptor type, O
PYCR1 pyrroline-5-carboxylate reductase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SSR4 signal sequence receptor, delta
TMED3 transmembrane emp24 protein transport domain containing 3
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
WDR61 WD repeat domain 61
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
C6ORF62 chromosome 6 open reading frame 62
CADPS2 Ca++-dependent secretion activator 2
CBR3 carbonyl reductase 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLEC11A C-type lectin domain family 11, member A
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
KANK2 KN motif and ankyrin repeat domains 2
KLF4 Kruppel-like factor 4 (gut)
MAGEA12 melanoma antigen family A12
MAGEA5 melanoma antigen family A5
NR4A2 nuclear receptor subfamily 4, group A, member 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RGS2 regulator of G-protein signaling 2
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SET SET nuclear proto-oncogene
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPRED2 sprouty-related, EVH1 domain containing 2
TMEM164 transmembrane protein 164
VCAN versican