BRD-K19166598_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K19166598_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADM adrenomedullin
APOD apolipoprotein D
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
CA2 carbonic anhydrase II
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
FABP7 fatty acid binding protein 7, brain
GARS glycyl-tRNA synthetase
GEM GTP binding protein overexpressed in skeletal muscle
GLDC glycine dehydrogenase (decarboxylating)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2AC histone cluster 1, H2ac
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MGLL monoglyceride lipase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
QPCT glutaminyl-peptide cyclotransferase
RHOB ras homolog family member B
RNF19B ring finger protein 19B
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STC2 stanniocalcin 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TRPS1 trichorhinophalangeal syndrome I
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
VCAN versican
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BST2 bone marrow stromal cell antigen 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAST calpastatin
CFI complement factor I
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
GNAS GNAS complex locus
GOLGA8A golgin A8 family, member A
HSPA1A heat shock 70kDa protein 1A
IFI6 interferon, alpha-inducible protein 6
IFITM3 interferon induced transmembrane protein 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPD1 LY6/PLAUR domain containing 1
MOK MOK protein kinase
MSRB2 methionine sulfoxide reductase B2
MXRA7 matrix-remodelling associated 7
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OLFM4 olfactomedin 4
OXA1L oxidase (cytochrome c) assembly 1-like
PFN2 profilin 2
PSPH phosphoserine phosphatase
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TMSB15A thymosin beta 15a
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
YME1L1 YME1-like 1 ATPase