BRD-K19166598_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K19166598_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ANPEP alanyl (membrane) aminopeptidase
AOAH acyloxyacyl hydrolase (neutrophil)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX1 brain expressed, X-linked 1
BID BH3 interacting domain death agonist
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL8 chemokine (C-C motif) ligand 8
CCND2 cyclin D2
CCR1 chemokine (C-C motif) receptor 1
CD86 CD86 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHMP4A charged multivesicular body protein 4A
CHN2 chimerin 2
CLEC4A C-type lectin domain family 4, member A
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FADS1 fatty acid desaturase 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
IFIH1 interferon induced with helicase C domain 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
KDM5D lysine (K)-specific demethylase 5D
KIAA0226L KIAA0226-like
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LGALS2 lectin, galactoside-binding, soluble, 2
METTL7A methyltransferase like 7A
MKNK1 MAP kinase interacting serine/threonine kinase 1
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNASE6 ribonuclease, RNase A family, k6
RTN1 reticulon 1
SATB2 SATB homeobox 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC63 SEC63 homolog (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
STC2 stanniocalcin 2
SUB1 SUB1 homolog (S. cerevisiae)
TF transferrin
TFF3 trefoil factor 3 (intestinal)
TMEM176B transmembrane protein 176B
TRIB3 tribbles pseudokinase 3
TSPYL5 TSPY-like 5
UBXN4 UBX domain protein 4
VCAN versican
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANXA6 annexin A6
ARG1 arginase 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND3 cyclin D3
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDC25A cell division cycle 25A
CRISP3 cysteine-rich secretory protein 3
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTTN cortactin
CYTL1 cytokine-like 1
DBN1 drebrin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM46A family with sequence similarity 46, member A
GAS1 growth arrest-specific 1
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
IGKV1-5 immunoglobulin kappa variable 1-5
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAOB monoamine oxidase B
MARCKSL1 MARCKS-like 1
MFSD10 major facilitator superfamily domain containing 10
MYCBP MYC binding protein
NNMT nicotinamide N-methyltransferase
NXN nucleoredoxin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTRF polymerase I and transcript release factor
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SRPX sushi-repeat containing protein, X-linked
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TBC1D16 TBC1 domain family, member 16
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM45A transmembrane protein 45A
TPM4 tropomyosin 4
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN3 tetraspanin 3
VAT1 vesicle amine transport 1
WDR1 WD repeat domain 1
XIST X inactive specific transcript (non-protein coding)
ZYX zyxin
Funding