BRD-K19166598_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K19166598_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BHLHE40 basic helix-loop-helix family, member e40
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
ELANE elastase, neutrophil expressed
EREG epiregulin
FKBP11 FK506 binding protein 11, 19 kDa
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LTF lactotransferrin
MBNL2 muscleblind-like splicing regulator 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCF4 neutrophil cytosolic factor 4, 40kDa
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PSAT1 phosphoserine aminotransferase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
STC2 stanniocalcin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ATF5 activating transcription factor 5
BCHE butyrylcholinesterase
DLD dihydrolipoamide dehydrogenase
GJA1 gap junction protein, alpha 1, 43kDa
GOLGA8A golgin A8 family, member A
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPH1 heat shock 105kDa/110kDa protein 1
MAT2A methionine adenosyltransferase II, alpha
NOP16 NOP16 nucleolar protein
NUAK1 NUAK family, SNF1-like kinase, 1
PCP4 Purkinje cell protein 4
PPIF peptidylprolyl isomerase F
RHOBTB3 Rho-related BTB domain containing 3
S100A2 S100 calcium binding protein A2
TFPI2 tissue factor pathway inhibitor 2
WWC1 WW and C2 domain containing 1
ZNF185 zinc finger protein 185 (LIM domain)
Funding