BRD-K19181733_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K19181733_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ALCAM activated leukocyte cell adhesion molecule
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
CD36 CD36 molecule (thrombospondin receptor)
CD99 CD99 molecule
CDK19 cyclin-dependent kinase 19
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
HAL histidine ammonia-lyase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDE insulin-degrading enzyme
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44L interferon-induced protein 44-like
LDLR low density lipoprotein receptor
LPL lipoprotein lipase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMO1 methylsterol monooxygenase 1
NOTCH2NL notch 2 N-terminal like
PGD phosphogluconate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPARG peroxisome proliferator-activated receptor gamma
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SPTBN1 spectrin, beta, non-erythrocytic 1
SQLE squalene epoxidase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
ADA adenosine deaminase
ADIRF adipogenesis regulatory factor
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
C3 complement component 3
CD24 CD24 molecule
CDC20 cell division cycle 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CP ceruloplasmin (ferroxidase)
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPYSL3 dihydropyrimidinase-like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
FOLR1 folate receptor 1 (adult)
HIST1H4C histone cluster 1, H4c
HOPX HOP homeobox
IFRD2 interferon-related developmental regulator 2
IGFBP5 insulin-like growth factor binding protein 5
ISOC1 isochorismatase domain containing 1
MAT2A methionine adenosyltransferase II, alpha
NNMT nicotinamide N-methyltransferase
PCNA proliferating cell nuclear antigen
PMM2 phosphomannomutase 2
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RNF167 ring finger protein 167
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
TFRC transferrin receptor
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN12 tetraspanin 12
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