BRD-K19220233_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

233 genes differentially expressed following the BRD-K19220233_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
BEX4 brain expressed, X-linked 4
BGN biglycan
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH13 cadherin 13
CEP70 centrosomal protein 70kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSZ cathepsin Z
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP1 fatty acid binding protein 1, liver
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FST follistatin
GAGE3 G antigen 3
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GPR161 G protein-coupled receptor 161
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
INA internexin neuronal intermediate filament protein, alpha
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0226L KIAA0226-like
LMO3 LIM domain only 3 (rhombotin-like 2)
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
NID1 nidogen 1
NPTX2 neuronal pentraxin II
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE8B phosphodiesterase 8B
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLVAP plasmalemma vesicle associated protein
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOCS2 suppressor of cytokine signaling 2
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
SULF1 sulfatase 1
SV2A synaptic vesicle glycoprotein 2A
TBX3 T-box 3
TFPI2 tissue factor pathway inhibitor 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRHDE thyrotropin-releasing hormone degrading enzyme
TSPAN12 tetraspanin 12
TSPAN7 tetraspanin 7

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARFIP2 ADP-ribosylation factor interacting protein 2
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AURKA aurora kinase A
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BCAS3 breast carcinoma amplified sequence 3
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CD164 CD164 molecule, sialomucin
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CGRRF1 cell growth regulator with ring finger domain 1
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT7 CCR4-NOT transcription complex, subunit 7
COIL coilin
COMMD3 COMM domain containing 3
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ERBB2 erb-b2 receptor tyrosine kinase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM35A family with sequence similarity 35, member A
FASTKD5 FAST kinase domains 5
FXYD3 FXYD domain containing ion transport regulator 3
GABPB1 GA binding protein transcription factor, beta subunit 1
GCH1 GTP cyclohydrolase 1
GDI2 GDP dissociation inhibitor 2
GLOD4 glyoxalase domain containing 4
GRWD1 glutamate-rich WD repeat containing 1
GTPBP8 GTP-binding protein 8 (putative)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KANSL2 KAT8 regulatory NSL complex subunit 2
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT7 keratin 7, type II
KYNU kynureninase
LTF lactotransferrin
LXN latexin
MAPK6 mitogen-activated protein kinase 6
MARCKSL1 MARCKS-like 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPS30 mitochondrial ribosomal protein S30
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBPC1 myosin binding protein C, slow type
NMD3 NMD3 ribosome export adaptor
NOP56 NOP56 ribonucleoprotein
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OPN3 opsin 3
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRPF4 pre-mRNA processing factor 4
PRSS23 protease, serine, 23
PTGES prostaglandin E synthase
RAE1 ribonucleic acid export 1
RET ret proto-oncogene
RFK riboflavin kinase
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SEPHS1 selenophosphate synthetase 1
SF3B5 splicing factor 3b, subunit 5, 10kDa
SFN stratifin
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRPRB signal recognition particle receptor, B subunit
SUCO SUN domain containing ossification factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TMEM251 transmembrane protein 251
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TPD52L1 tumor protein D52-like 1
TRAPPC3 trafficking protein particle complex 3
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
TXNDC9 thioredoxin domain containing 9
UBE2C ubiquitin-conjugating enzyme E2C
VCPKMT valosin containing protein lysine (K) methyltransferase
VEZF1 vascular endothelial zinc finger 1
XBP1 X-box binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
Funding