BRD-K19220233_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K19220233_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ARL4C ADP-ribosylation factor-like 4C
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CFB complement factor B
CPM carboxypeptidase M
CTGF connective tissue growth factor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
FABP1 fatty acid binding protein 1, liver
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FST follistatin
GIPC2 GIPC PDZ domain containing family, member 2
GPM6A glycoprotein M6A
HSPG2 heparan sulfate proteoglycan 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
MAOA monoamine oxidase A
MSN moesin
NLRP2 NLR family, pyrin domain containing 2
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PKP2 plakophilin 2
PRAME preferentially expressed antigen in melanoma
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TPSAB1 tryptase alpha/beta 1
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ATF5 activating transcription factor 5
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BLCAP bladder cancer associated protein
CANT1 calcium activated nucleotidase 1
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLP1 cleavage and polyadenylation factor I subunit 1
COIL coilin
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ESR1 estrogen receptor 1
FASTKD5 FAST kinase domains 5
FBXO34 F-box protein 34
FEN1 flap structure-specific endonuclease 1
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
HEXIM1 hexamethylene bis-acetamide inducible 1
HN1 hematological and neurological expressed 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INSIG1 insulin induced gene 1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KIN Kin17 DNA and RNA binding protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LMO2 LIM domain only 2 (rhombotin-like 1)
LXN latexin
MAPK6 mitogen-activated protein kinase 6
MCM10 minichromosome maintenance complex component 10
MED17 mediator complex subunit 17
MFSD5 major facilitator superfamily domain containing 5
MSH6 mutS homolog 6
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NUPL1 nucleoporin like 1
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PELO pelota homolog (Drosophila)
PFKP phosphofructokinase, platelet
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK2 polo-like kinase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PROM1 prominin 1
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTRH2 peptidyl-tRNA hydrolase 2
RABIF RAB interacting factor
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RBM12 RNA binding motif protein 12
RBM15 RNA binding motif protein 15
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
RRP1B ribosomal RNA processing 1B
SCAF8 SR-related CTD-associated factor 8
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMG8 SMG8 nonsense mediated mRNA decay factor
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TBPL1 TBP-like 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TGIF1 TGFB-induced factor homeobox 1
THAP11 THAP domain containing 11
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUBA4A tubulin, alpha 4a
TUBD1 tubulin, delta 1
TXLNA taxilin alpha
TXNDC9 thioredoxin domain containing 9
UBE2S ubiquitin-conjugating enzyme E2S
VCPKMT valosin containing protein lysine (K) methyltransferase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB1 zinc finger and BTB domain containing 1
ZBTB11 zinc finger and BTB domain containing 11
Funding