BRD-K19220233_JNK-9L_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

306 genes differentially expressed following the BRD-K19220233_JNK-9L_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHNAK2 AHNAK nucleoprotein 2
AIF1 allograft inflammatory factor 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANK2 ankyrin 2, neuronal
ANKRD12 ankyrin repeat domain 12
APLP2 amyloid beta (A4) precursor-like protein 2
APOC2 apolipoprotein C-II
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF3 activating transcription factor 3
ATP13A3 ATPase type 13A3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
C2 complement component 2
C6ORF62 chromosome 6 open reading frame 62
CA11 carbonic anhydrase XI
CALB1 calbindin 1, 28kDa
CCDC6 coiled-coil domain containing 6
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCR1 chemokine (C-C motif) receptor 1
CD302 CD302 molecule
CD52 CD52 molecule
CD86 CD86 molecule
CDC42 cell division cycle 42
CECR1 cat eye syndrome chromosome region, candidate 1
CES2 carboxylesterase 2
CFB complement factor B
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP1B charged multivesicular body protein 1B
CLU clusterin
COASY CoA synthase
CRABP2 cellular retinoic acid binding protein 2
CTSB cathepsin B
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DCLK1 doublecortin-like kinase 1
DCX doublecortin
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB2 ephrin-B2
EGR1 early growth response 1
ELL2 elongation factor, RNA polymerase II, 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM107A family with sequence similarity 107, member A
FAM46A family with sequence similarity 46, member A
FAM63A family with sequence similarity 63, member A
FASTKD5 FAST kinase domains 5
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FRS2 fibroblast growth factor receptor substrate 2
FSD1 fibronectin type III and SPRY domain containing 1
GEM GTP binding protein overexpressed in skeletal muscle
GLS glutaminase
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNPDA1 glucosamine-6-phosphate deaminase 1
GPM6B glycoprotein M6B
GPR183 G protein-coupled receptor 183
GPX3 glutathione peroxidase 3
GSTT1 glutathione S-transferase theta 1
H2BFS H2B histone family, member S (pseudogene)
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HK1 hexokinase 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
INSIG1 insulin induced gene 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAM2 junctional adhesion molecule 2
KIF5C kinesin family member 5C
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LGALS1 lectin, galactoside-binding, soluble, 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOA monoamine oxidase A
MCTP1 multiple C2 domains, transmembrane 1
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP3 matrix metallopeptidase 3
MT1E metallothionein 1E
MT1F metallothionein 1F
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRIP1 nuclear receptor interacting protein 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
OLFM1 olfactomedin 1
PCP4 Purkinje cell protein 4
PDE2A phosphodiesterase 2A, cGMP-stimulated
PER2 period circadian clock 2
PHACTR1 phosphatase and actin regulator 1
PLAU plasminogen activator, urokinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLTP phospholipid transfer protein
PNMA1 paraneoplastic Ma antigen 1
PPAP2B phosphatidic acid phosphatase type 2B
PRDM2 PR domain containing 2, with ZNF domain
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PTN pleiotrophin
RAB2A RAB2A, member RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RASA4 RAS p21 protein activator 4
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGCC regulator of cell cycle
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RNASE6 ribonuclease, RNase A family, k6
RNMT RNA (guanine-7-) methyltransferase
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
RSL1D1 ribosomal L1 domain containing 1
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SDC4 syndecan 4
SDCBP syndecan binding protein (syntenin)
SELE selectin E
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNN stannin
SOD2 superoxide dismutase 2, mitochondrial
SOWAHC sosondowah ankyrin repeat domain family member C
SPARCL1 SPARC-like 1 (hevin)
SPEN spen family transcriptional repressor
SST somatostatin
STX1A syntaxin 1A (brain)
TCN2 transcobalamin II
TGM4 transglutaminase 4
TICAM1 toll-like receptor adaptor molecule 1
TKT transketolase
TPP1 tripeptidyl peptidase I
TRIO trio Rho guanine nucleotide exchange factor
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
USP36 ubiquitin specific peptidase 36
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein
ZFR zinc finger RNA binding protein
ZNF264 zinc finger protein 264
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADGRG6 adhesion G protein-coupled receptor G6
AEBP1 AE binding protein 1
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
ATF5 activating transcription factor 5
ATG3 autophagy related 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLVRA biliverdin reductase A
BMI1 BMI1 proto-oncogene, polycomb ring finger
C10ORF10 chromosome 10 open reading frame 10
C4ORF27 chromosome 4 open reading frame 27
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCND3 cyclin D3
CDC25A cell division cycle 25A
CENPE centromere protein E, 312kDa
CENPU centromere protein U
CHGB chromogranin B
CKAP4 cytoskeleton-associated protein 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL5A2 collagen, type V, alpha 2
COMMD3 COMM domain containing 3
CYB5R2 cytochrome b5 reductase 2
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPYSL2 dihydropyrimidinase-like 2
DUT deoxyuridine triphosphatase
ECD ecdysoneless homolog (Drosophila)
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV1 ets variant 1
FANCI Fanconi anemia, complementation group I
FLG filaggrin
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GTPBP8 GTP-binding protein 8 (putative)
H1F0 H1 histone family, member 0
HOXB7 homeobox B7
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI16 interferon, gamma-inducible protein 16
IGFBP4 insulin-like growth factor binding protein 4
IGSF3 immunoglobulin superfamily, member 3
IL20RA interleukin 20 receptor, alpha
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIAA1033 KIAA1033
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LCN2 lipocalin 2
LTF lactotransferrin
LUM lumican
MBNL1 muscleblind-like splicing regulator 1
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MSH2 mutS homolog 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYH10 myosin, heavy chain 10, non-muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK7 NIMA-related kinase 7
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NUP88 nucleoporin 88kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PON3 paraoxonase 3
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
RAD51AP1 RAD51 associated protein 1
RAD51C RAD51 paralog C
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
RYR1 ryanodine receptor 1 (skeletal)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SMC4 structural maintenance of chromosomes 4
SOSTDC1 sclerostin domain containing 1
SPDL1 spindle apparatus coiled-coil protein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
STOM stomatin
SYNM synemin, intermediate filament protein
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLE4 transducin-like enhancer of split 4
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)
UGP2 UDP-glucose pyrophosphorylase 2
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WNT5A wingless-type MMTV integration site family, member 5A
ZWINT ZW10 interacting kinetochore protein
Funding