BRD-K19220233_JNK-9L_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

209 genes differentially expressed following the BRD-K19220233_JNK-9L_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACP5 acid phosphatase 5, tartrate resistant
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
BHLHE40 basic helix-loop-helix family, member e40
BHMT2 betaine--homocysteine S-methyltransferase 2
BIRC3 baculoviral IAP repeat containing 3
BPIFA1 BPI fold containing family A, member 1
C2 complement component 2
C6ORF48 chromosome 6 open reading frame 48
C9ORF16 chromosome 9 open reading frame 16
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD200 CD200 molecule
CD84 CD84 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFI complement factor I
CIB2 calcium and integrin binding family member 2
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
CPE carboxypeptidase E
CREG1 cellular repressor of E1A-stimulated genes 1
CTSB cathepsin B
CTSO cathepsin O
CTSS cathepsin S
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS3 dehydrogenase/reductase (SDR family) member 3
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
ITFG1 integrin alpha FG-GAP repeat containing 1
KAT2B K(lysine) acetyltransferase 2B
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP3 lysosomal-associated membrane protein 3
LDHB lactate dehydrogenase B
LEFTY1 left-right determination factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2B2 mannosidase, alpha, class 2B, member 2
MEF2C myocyte enhancer factor 2C
MICB MHC class I polypeptide-related sequence B
MN1 meningioma (disrupted in balanced translocation) 1
MPP1 membrane protein, palmitoylated 1, 55kDa
MX1 MX dynamin-like GTPase 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NUPR1 nuclear protein, transcriptional regulator, 1
OVGP1 oviductal glycoprotein 1, 120kDa
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLS3 plastin 3
PRAME preferentially expressed antigen in melanoma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RPL31 ribosomal protein L31
RPS5 ribosomal protein S5
RRAGD Ras-related GTP binding D
RSAD2 radical S-adenosyl methionine domain containing 2
SCD5 stearoyl-CoA desaturase 5
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SH2D1A SH2 domain containing 1A
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STMN2 stathmin 2
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TPGS2 tubulin polyglutamylase complex subunit 2
TPMT thiopurine S-methyltransferase
TPP1 tripeptidyl peptidase I
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
VAT1 vesicle amine transport 1
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AHNAK AHNAK nucleoprotein
ANXA3 annexin A3
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNND1 catenin (cadherin-associated protein), delta 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
EAPP E2F-associated phosphoprotein
FEN1 flap structure-specific endonuclease 1
GAS1 growth arrest-specific 1
GAS2L1 growth arrest-specific 2 like 1
HMOX2 heme oxygenase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
ITGA6 integrin, alpha 6
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LBR lamin B receptor
METTL3 methyltransferase like 3
MKI67 marker of proliferation Ki-67
MRPL15 mitochondrial ribosomal protein L15
MRPS12 mitochondrial ribosomal protein S12
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP85 nucleoporin 85kDa
NXN nucleoredoxin
PCNA proliferating cell nuclear antigen
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PUF60 poly-U binding splicing factor 60KDa
PXDN peroxidasin
RASA1 RAS p21 protein activator (GTPase activating protein) 1
S100A10 S100 calcium binding protein A10
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC38A2 solute carrier family 38, member 2
SOX9 SRY (sex determining region Y)-box 9
STIP1 stress-induced phosphoprotein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMPO thymopoietin
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TUBA4A tubulin, alpha 4a
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
ZBTB16 zinc finger and BTB domain containing 16
ZFP36L2 ZFP36 ring finger protein-like 2
Funding