BRD-K19220233_JNK-9L_HT29_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K19220233_JNK-9L_HT29_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
ANKRD10 ankyrin repeat domain 10
ARMCX2 armadillo repeat containing, X-linked 2
ASPN asporin
CD44 CD44 molecule (Indian blood group)
CLIC5 chloride intracellular channel 5
E2F2 E2F transcription factor 2
EPCAM epithelial cell adhesion molecule
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS1 fatty acid desaturase 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FXYD6 FXYD domain containing ion transport regulator 6
HEBP1 heme binding protein 1
HIST1H2BK histone cluster 1, H2bk
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
LRRC15 leucine rich repeat containing 15
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
NEB nebulin
NID2 nidogen 2 (osteonidogen)
PALLD palladin, cytoskeletal associated protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHYH phytanoyl-CoA 2-hydroxylase
PNKP polynucleotide kinase 3'-phosphatase
QPCT glutaminyl-peptide cyclotransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS10 regulator of G-protein signaling 10
SORBS3 sorbin and SH3 domain containing 3
ST14 suppression of tumorigenicity 14 (colon carcinoma)
TNNT1 troponin T type 1 (skeletal, slow)
TRAPPC6A trafficking protein particle complex 6A

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP1 aquaporin 1 (Colton blood group)
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AUTS2 autism susceptibility candidate 2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CD69 CD69 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CST7 cystatin F (leukocystatin)
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM46C family with sequence similarity 46, member C
FGF13 fibroblast growth factor 13
GLRX glutaredoxin (thioltransferase)
GPC4 glypican 4
GREM1 gremlin 1, DAN family BMP antagonist
GZMK granzyme K (granzyme 3; tryptase II)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MAN1C1 mannosidase, alpha, class 1C, member 1
MCAM melanoma cell adhesion molecule
MCL1 myeloid cell leukemia 1
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTSS1 metastasis suppressor 1
NEBL nebulette
PLA2G16 phospholipase A2, group XVI
POU2AF1 POU class 2 associating factor 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRTN3 proteinase 3
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
RND3 Rho family GTPase 3
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STOM stomatin
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TLE4 transducin-like enhancer of split 4
TNC tenascin C
TOX thymocyte selection-associated high mobility group box
TPM4 tropomyosin 4
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
Funding