BRD-K19220233_JNK-9L_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

265 genes differentially expressed following the BRD-K19220233_JNK-9L_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
AOX1 aldehyde oxidase 1
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
ARHGAP29 Rho GTPase activating protein 29
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATOX1 antioxidant 1 copper chaperone
AXL AXL receptor tyrosine kinase
BACE2 beta-site APP-cleaving enzyme 2
BHLHE40 basic helix-loop-helix family, member e40
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CD47 CD47 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
COLEC12 collectin sub-family member 12
CTGF connective tissue growth factor
CTSL cathepsin L
CTTN cortactin
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK1 death-associated protein kinase 1
DCTD dCMP deaminase
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENOSF1 enolase superfamily member 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGFR4 fibroblast growth factor receptor 4
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FRY furry homolog (Drosophila)
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GHR growth hormone receptor
GOLM1 golgi membrane protein 1
GP2 glycoprotein 2 (zymogen granule membrane)
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HLA-E major histocompatibility complex, class I, E
HLTF helicase-like transcription factor
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KIAA1598
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LEF1 lymphoid enhancer-binding factor 1
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2B2 mannosidase, alpha, class 2B, member 2
MAOA monoamine oxidase A
MEG3 maternally expressed 3 (non-protein coding)
MFSD10 major facilitator superfamily domain containing 10
MLF1 myeloid leukemia factor 1
MN1 meningioma (disrupted in balanced translocation) 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MZT2A mitotic spindle organizing protein 2A
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NENF neudesin neurotrophic factor
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCCB propionyl CoA carboxylase, beta polypeptide
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PENK proenkephalin
PFN2 profilin 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRAME preferentially expressed antigen in melanoma
PROS1 protein S (alpha)
PROSC proline synthetase co-transcribed homolog (bacterial)
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
REEP5 receptor accessory protein 5
RGS1 regulator of G-protein signaling 1
RNMT RNA (guanine-7-) methyltransferase
RPL31 ribosomal protein L31
SAT1 spermidine/spermine N1-acetyltransferase 1
SCP2 sterol carrier protein 2
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SSR4 signal sequence receptor, delta
ST7 suppression of tumorigenicity 7
STC1 stanniocalcin 1
STXBP2 syntaxin binding protein 2
SYBU syntabulin (syntaxin-interacting)
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
THBD thrombomodulin
THBS4 thrombospondin 4
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN3 tetraspanin 3
TSPAN31 tetraspanin 31
TSPAN7 tetraspanin 7
TSTA3 tissue specific transplantation antigen P35B
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
VAT1 vesicle amine transport 1
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRG2 adhesion G protein-coupled receptor G2
AIM1 absent in melanoma 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTBD3 BTB (POZ) domain containing 3
CASD1 CAS1 domain containing 1
CAST calpastatin
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
CHN1 chimerin 1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL14 chemokine (C-X-C motif) ligand 14
ERBB2 erb-b2 receptor tyrosine kinase 2
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGBP Fc fragment of IgG binding protein
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GTPBP8 GTP-binding protein 8 (putative)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HOXA5 homeobox A5
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
IL1R2 interleukin 1 receptor, type II
JMJD6 jumonji domain containing 6
KRT13 keratin 13, type I
KRT15 keratin 15, type I
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
MCM4 minichromosome maintenance complex component 4
MPZL2 myelin protein zero-like 2
MREG melanoregulin
MSL1 male-specific lethal 1 homolog (Drosophila)
MSMB microseminoprotein, beta-
NET1 neuroepithelial cell transforming 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NXN nucleoredoxin
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PANK2 pantothenate kinase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCNA proliferating cell nuclear antigen
PDHX pyruvate dehydrogenase complex, component X
PDZRN3 PDZ domain containing ring finger 3
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RAE1 ribonucleic acid export 1
RBM38 RNA binding motif protein 38
RIN2 Ras and Rab interactor 2
RNPS1 RNA binding protein S1, serine-rich domain
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCAND1 SCAN domain containing 1
SHB Src homology 2 domain containing adaptor protein B
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD1 SMAD family member 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPINK1 serine peptidase inhibitor, Kazal type 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TFRC transferrin receptor
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRAPPC3 trafficking protein particle complex 3
TRIM29 tripartite motif containing 29
UBE3C ubiquitin protein ligase E3C
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
ZNF217 zinc finger protein 217
Funding