BRD-K19220233_JNK-9L_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K19220233_JNK-9L_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD36B ankyrin repeat domain 36B
BST2 bone marrow stromal cell antigen 2
C9ORF16 chromosome 9 open reading frame 16
CD59 CD59 molecule, complement regulatory protein
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
COCH cochlin
COL9A3 collagen, type IX, alpha 3
EPHA3 EPH receptor A3
FXYD5 FXYD domain containing ion transport regulator 5
GPC3 glypican 3
IFITM1 interferon induced transmembrane protein 1
INPP5F inositol polyphosphate-5-phosphatase F
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LTA4H leukotriene A4 hydrolase
MAGEA3 melanoma antigen family A3
MBOAT2 membrane bound O-acyltransferase domain containing 2
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLF1 myeloid leukemia factor 1
NKTR natural killer cell triggering receptor
NPTX2 neuronal pentraxin II
NTS neurotensin
OSBPL10 oxysterol binding protein-like 10
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAP2A RAP2A, member of RAS oncogene family
RBP1 retinol binding protein 1, cellular
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS11 ribosomal protein S11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPAG4 sperm associated antigen 4
SPRR3 small proline-rich protein 3
STK10 serine/threonine kinase 10
TM4SF1 transmembrane 4 L six family member 1

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AMD1 adenosylmethionine decarboxylase 1
AMOTL2 angiomotin like 2
AQP3 aquaporin 3 (Gill blood group)
AURKB aurora kinase B
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCND2 cyclin D2
CCNE2 cyclin E2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHTOP chromatin target of PRMT1
COL15A1 collagen, type XV, alpha 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FZD5 frizzled class receptor 5
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IER5 immediate early response 5
JMJD6 jumonji domain containing 6
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MID1IP1 MID1 interacting protein 1
MMP3 matrix metallopeptidase 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NRIP1 nuclear receptor interacting protein 1
NXN nucleoredoxin
PRNP prion protein
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RND3 Rho family GTPase 3
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN2 reticulon 2
RYBP RING1 and YY1 binding protein
SCGB2A1 secretoglobin, family 2A, member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
STX3 syntaxin 3
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
TOB2 transducer of ERBB2, 2
TUFT1 tuftelin 1
WASL Wiskott-Aldrich syndrome-like
ZBTB10 zinc finger and BTB domain containing 10
ZBTB18 zinc finger and BTB domain containing 18
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
Funding