BRD-K19220233_JNK-9L_MCF10A_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

255 genes differentially expressed following the BRD-K19220233_JNK-9L_MCF10A_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOE apolipoprotein E
AQP9 aquaporin 9
ASPN asporin
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATXN1 ataxin 1
BAALC brain and acute leukemia, cytoplasmic
BHLHE40 basic helix-loop-helix family, member e40
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCR1 chemokine (C-C motif) receptor 1
CD34 CD34 molecule
CD4 CD4 molecule
CD9 CD9 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEP70 centrosomal protein 70kDa
CFI complement factor I
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSK cathepsin K
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDR2 discoidin domain receptor tyrosine kinase 2
DEFB1 defensin, beta 1
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
ECM1 extracellular matrix protein 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EML1 echinoderm microtubule associated protein like 1
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FHL1 four and a half LIM domains 1
FRY furry homolog (Drosophila)
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GLT8D2 glycosyltransferase 8 domain containing 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
ITGAV integrin, alpha V
JAM2 junctional adhesion molecule 2
LGALS3 lectin, galactoside-binding, soluble, 3
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAN2B2 mannosidase, alpha, class 2B, member 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NCF2 neutrophil cytosolic factor 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTM neurotrimin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAU plasminogen activator, urokinase
PLIN1 perilipin 1
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PROS1 protein S (alpha)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
QPRT quinolinate phosphoribosyltransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
RHOQ ras homolog family member Q
RNASET2 ribonuclease T2
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARCL1 SPARC-like 1 (hevin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SSR4 signal sequence receptor, delta
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
TCF4 transcription factor 4
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM45A transmembrane protein 45A
TNIP1 TNFAIP3 interacting protein 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TWIST1 twist family bHLH transcription factor 1
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKAP1 A kinase (PRKA) anchor protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ATG3 autophagy related 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BUB3 BUB3 mitotic checkpoint protein
CACYBP calcyclin binding protein
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
CSE1L CSE1 chromosome segregation 1-like (yeast)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FBL fibrillarin
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GCH1 GTP cyclohydrolase 1
H2AFZ H2A histone family, member Z
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
KRT15 keratin 15, type I
KRT23 keratin 23, type I
LBR lamin B receptor
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MKNK2 MAP kinase interacting serine/threonine kinase 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
NET1 neuroepithelial cell transforming 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PCNA proliferating cell nuclear antigen
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PTBP1 polypyrimidine tract binding protein 1
RAE1 ribonucleic acid export 1
RBM14 RNA binding motif protein 14
RNPS1 RNA binding protein S1, serine-rich domain
RRM2 ribonucleotide reductase M2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLIRP SRA stem-loop interacting RNA binding protein
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SORBS2 sorbin and SH3 domain containing 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF3 serine/arginine-rich splicing factor 3
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMPO thymopoietin
TRAPPC3 trafficking protein particle complex 3
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2I ubiquitin-conjugating enzyme E2I
UBE2S ubiquitin-conjugating enzyme E2S
USP22 ubiquitin specific peptidase 22
WEE1 WEE1 G2 checkpoint kinase
ZDHHC6 zinc finger, DHHC-type containing 6
Funding