BRD-K19220233_JNK-9L_MCF7_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K19220233_JNK-9L_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AXL AXL receptor tyrosine kinase
BCHE butyrylcholinesterase
BHLHE40 basic helix-loop-helix family, member e40
CDH3 cadherin 3, type 1, P-cadherin (placental)
CLEC2B C-type lectin domain family 2, member B
CRTAP cartilage associated protein
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDHD2 DDHD domain containing 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
ECHDC2 enoyl CoA hydratase domain containing 2
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FBLN1 fibulin 1
FGFR1 fibroblast growth factor receptor 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXF1 forkhead box F1
FST follistatin
GAA glucosidase, alpha; acid
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GUK1 guanylate kinase 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIST1H2BC histone cluster 1, H2bc
HLA-C major histocompatibility complex, class I, C
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL1A interleukin 1, alpha
KLF2 Kruppel-like factor 2
LDHB lactate dehydrogenase B
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100272216 uncharacterized LOC100272216
MAN2B2 mannosidase, alpha, class 2B, member 2
MSN moesin
MSX1 msh homeobox 1
MXRA7 matrix-remodelling associated 7
NMU neuromedin U
NPDC1 neural proliferation, differentiation and control, 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRIP3 nuclear receptor interacting protein 3
NRN1 neuritin 1
PER3 period circadian clock 3
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PLVAP plasmalemma vesicle associated protein
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGS1 regulator of G-protein signaling 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC35G2 solute carrier family 35, member G2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TYROBP TYRO protein tyrosine kinase binding protein
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANXA3 annexin A3
ARMCX2 armadillo repeat containing, X-linked 2
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
CCNB2 cyclin B2
CD24 CD24 molecule
CDC20 cell division cycle 20
CKS2 CDC28 protein kinase regulatory subunit 2
COA3 cytochrome c oxidase assembly factor 3
CRNKL1 crooked neck pre-mRNA splicing factor 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAPP E2F-associated phosphoprotein
GLOD4 glyoxalase domain containing 4
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LTF lactotransferrin
LXN latexin
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
OPN3 opsin 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCNA proliferating cell nuclear antigen
PDCD10 programmed cell death 10
PHF20 PHD finger protein 20
PNP purine nucleoside phosphorylase
RAE1 ribonucleic acid export 1
SCAND1 SCAN domain containing 1
SFN stratifin
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFRC transferrin receptor
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
XBP1 X-box binding protein 1
Funding