BRD-K19220233_JNK-9L_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K19220233_JNK-9L_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOX2 acyl-CoA oxidase 2, branched chain
ACSM5 acyl-CoA synthetase medium-chain family member 5
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA1 annexin A1
ANXA10 annexin A10
APOE apolipoprotein E
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BAALC brain and acute leukemia, cytoplasmic
BCHE butyrylcholinesterase
BHLHE40 basic helix-loop-helix family, member e40
BMP2 bone morphogenetic protein 2
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFI complement factor I
CLEC2B C-type lectin domain family 2, member B
CRTAP cartilage associated protein
CSRP2 cysteine and glycine-rich protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ETNPPL ethanolamine-phosphate phospho-lyase
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM107A family with sequence similarity 107, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
HBE1 hemoglobin, epsilon 1
HBEGF heparin-binding EGF-like growth factor
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HSDL2 hydroxysteroid dehydrogenase like 2
IFI16 interferon, gamma-inducible protein 16
IGFBP7 insulin-like growth factor binding protein 7
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF9 Kruppel-like factor 9
LDHB lactate dehydrogenase B
LEFTY1 left-right determination factor 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MSN moesin
MSX1 msh homeobox 1
MT1E metallothionein 1E
MXRA7 matrix-remodelling associated 7
MYRIP myosin VIIA and Rab interacting protein
NDRG2 NDRG family member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE8B phosphodiesterase 8B
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLTP phospholipid transfer protein
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RNASET2 ribonuclease T2
SCD5 stearoyl-CoA desaturase 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC35G2 solute carrier family 35, member G2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPRY2 sprouty homolog 2 (Drosophila)
STC1 stanniocalcin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TPP1 tripeptidyl peptidase I
TRHDE thyrotropin-releasing hormone degrading enzyme
TSPAN7 tetraspanin 7
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG2 adhesion G protein-coupled receptor G2
ANXA3 annexin A3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
CCNB2 cyclin B2
CD24 CD24 molecule
CDC20 cell division cycle 20
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
GCH1 GTP cyclohydrolase 1
GLOD4 glyoxalase domain containing 4
GREB1 growth regulation by estrogen in breast cancer 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLHL21 kelch-like family member 21
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LTF lactotransferrin
MSMB microseminoprotein, beta-
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NPY1R neuropeptide Y receptor Y1
ODC1 ornithine decarboxylase 1
PCNA proliferating cell nuclear antigen
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
RAE1 ribonucleic acid export 1
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFRC transferrin receptor
TMX4 thioredoxin-related transmembrane protein 4
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
Funding