BRD-K19220233_JNK-9L_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K19220233_JNK-9L_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CBX1 chromobox homolog 1
CD200 CD200 molecule
CHMP4A charged multivesicular body protein 4A
CLIC5 chloride intracellular channel 5
COTL1 coactosin-like F-actin binding protein 1
CPM carboxypeptidase M
GPX3 glutathione peroxidase 3
GSTT1 glutathione S-transferase theta 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXC6 homeobox C6
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
KLK6 kallikrein-related peptidase 6
LAGE3 L antigen family, member 3
LIMCH1 LIM and calponin homology domains 1
MDFIC MyoD family inhibitor domain containing
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NDN necdin, melanoma antigen (MAGE) family member
PALLD palladin, cytoskeletal associated protein
PEG3 paternally expressed 3
PLAT plasminogen activator, tissue
POSTN periostin, osteoblast specific factor
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPG11 spastic paraplegia 11 (autosomal recessive)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM100 transmembrane protein 100
TP53I3 tumor protein p53 inducible protein 3
TSPAN12 tetraspanin 12
VWA5A von Willebrand factor A domain containing 5A

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
BCL6 B-cell CLL/lymphoma 6
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC6 cell division cycle 6
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DIEXF digestive organ expansion factor homolog (zebrafish)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
FBXL12 F-box and leucine-rich repeat protein 12
FBXO34 F-box protein 34
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITGA6 integrin, alpha 6
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KRT5 keratin 5, type II
LPIN1 lipin 1
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFM neurofilament, medium polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NRIP1 nuclear receptor interacting protein 1
OSR2 odd-skipped related transciption factor 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RPL37A ribosomal protein L37a
RPP38 ribonuclease P/MRP 38kDa subunit
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SHOX2 short stature homeobox 2
SMAD3 SMAD family member 3
SOCS1 suppressor of cytokine signaling 1
SOX9 SRY (sex determining region Y)-box 9
SRSF7 serine/arginine-rich splicing factor 7
TARP TCR gamma alternate reading frame protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLK2 tousled-like kinase 2
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase
WLS wntless Wnt ligand secretion mediator
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF107 zinc finger protein 107
ZNF394 zinc finger protein 394
Funding