BRD-K19295594_-666_U937_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K19295594_-666_U937_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADM adrenomedullin
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CD24 CD24 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLCA1 chloride channel accessory 1
CLIC4 chloride intracellular channel 4
COG5 component of oligomeric golgi complex 5
CRABP1 cellular retinoic acid binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL14 chemokine (C-X-C motif) ligand 14
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DUOX2 dual oxidase 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FHL1 four and a half LIM domains 1
FOXF1 forkhead box F1
GARS glycyl-tRNA synthetase
GPA33 glycoprotein A33 (transmembrane)
GRB10 growth factor receptor-bound protein 10
GULP1 GULP, engulfment adaptor PTB domain containing 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG20 interferon stimulated exonuclease gene 20kDa
JAM2 junctional adhesion molecule 2
KLF6 Kruppel-like factor 6
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS4 lectin, galactoside-binding, soluble, 4
MAB21L2 mab-21-like 2 (C. elegans)
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MT1E metallothionein 1E
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFIL3 nuclear factor, interleukin 3 regulated
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
RAB21 RAB21, member RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF114 ring finger protein 114
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SHB Src homology 2 domain containing adaptor protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX11 SRY (sex determining region Y)-box 11
SOX9 SRY (sex determining region Y)-box 9
SPINK4 serine peptidase inhibitor, Kazal type 4
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SWAP70 SWAP switching B-cell complex 70kDa subunit
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BAG3 BCL2-associated athanogene 3
BST2 bone marrow stromal cell antigen 2
C2CD2 C2 calcium-dependent domain containing 2
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CD200 CD200 molecule
CHERP calcium homeostasis endoplasmic reticulum protein
COL7A1 collagen, type VII, alpha 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
EGR3 early growth response 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FAM57A family with sequence similarity 57, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
HAL histidine ammonia-lyase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
JADE2 jade family PHD finger 2
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LINC00341 long intergenic non-protein coding RNA 341
LY6D lymphocyte antigen 6 complex, locus D
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MNDA myeloid cell nuclear differentiation antigen
NKX3-1 NK3 homeobox 1
PEX6 peroxisomal biogenesis factor 6
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
RAB5C RAB5C, member RAS oncogene family
RPL22 ribosomal protein L22
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TPM4 tropomyosin 4
TSPAN8 tetraspanin 8
TUSC3 tumor suppressor candidate 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
XPO7 exportin 7
Funding