BRD-K19540840_saracatinib_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K19540840_saracatinib_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
ANXA3 annexin A3
AQP1 aquaporin 1 (Colton blood group)
ARG1 arginase 1
ARL4C ADP-ribosylation factor-like 4C
BEX1 brain expressed, X-linked 1
BMP4 bone morphogenetic protein 4
C1R complement component 1, r subcomponent
CCL2 chemokine (C-C motif) ligand 2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHRDL1 chordin-like 1
CLU clusterin
CTSC cathepsin C
CXADR coxsackie virus and adenovirus receptor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DUSP5 dual specificity phosphatase 5
FAM107A family with sequence similarity 107, member A
FHL1 four and a half LIM domains 1
GBP1 guanylate binding protein 1, interferon-inducible
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-F major histocompatibility complex, class I, F
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA4L heat shock 70kDa protein 4-like
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFI35 interferon-induced protein 35
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INSM1 insulinoma-associated 1
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
KAZN kazrin, periplakin interacting protein
L1CAM L1 cell adhesion molecule
LTF lactotransferrin
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MX1 MX dynamin-like GTPase 1
NEFH neurofilament, heavy polypeptide
NMI N-myc (and STAT) interactor
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PARP12 poly (ADP-ribose) polymerase family, member 12
PCP4 Purkinje cell protein 4
PLP1 proteolipid protein 1
PLSCR1 phospholipid scramblase 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYCARD PYD and CARD domain containing
QDPR quinoid dihydropteridine reductase
RAB13 RAB13, member RAS oncogene family
RSAD2 radical S-adenosyl methionine domain containing 2
SDC1 syndecan 1
SFN stratifin
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SP110 SP110 nuclear body protein
SPON1 spondin 1, extracellular matrix protein
SQRDL sulfide quinone reductase-like (yeast)
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
THEMIS2 thymocyte selection associated family member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM14 tripartite motif containing 14
TRIM2 tripartite motif containing 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VNN1 vanin 1

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRG1 adhesion G protein-coupled receptor G1
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CD99 CD99 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CLIC3 chloride intracellular channel 3
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CRLF1 cytokine receptor-like factor 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGF epidermal growth factor
EGR1 early growth response 1
EPHB2 EPH receptor B2
FN1 fibronectin 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GRB10 growth factor receptor-bound protein 10
GREB1 growth regulation by estrogen in breast cancer 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HAS2 hyaluronan synthase 2
HOXC6 homeobox C6
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
LOX lysyl oxidase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSPH phosphoserine phosphatase
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
RGS4 regulator of G-protein signaling 4
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
THBS1 thrombospondin 1
TM9SF3 transmembrane 9 superfamily member 3
TPM1 tropomyosin 1 (alpha)
VCAN versican
VEGFA vascular endothelial growth factor A
WWP1 WW domain containing E3 ubiquitin protein ligase 1
Funding