BRD-K19687926_lapatinib_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K19687926_lapatinib_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BPGM 2,3-bisphosphoglycerate mutase
C1ORF54 chromosome 1 open reading frame 54
CCNG2 cyclin G2
CHN1 chimerin 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
E2F2 E2F transcription factor 2
FGFR3 fibroblast growth factor receptor 3
KRAS Kirsten rat sarcoma viral oncogene homolog
LIPA lipase A, lysosomal acid, cholesterol esterase
MYO6 myosin VI
NOTCH2NL notch 2 N-terminal like
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPAG4 sperm associated antigen 4
TOB1 transducer of ERBB2, 1
TUFT1 tuftelin 1
VIM vimentin

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
C7 complement component 7
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CCND1 cyclin D1
CHGB chromogranin B
CLIC5 chloride intracellular channel 5
COCH cochlin
COL18A1 collagen, type XVIII, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
EXT1 exostosin glycosyltransferase 1
F5 coagulation factor V (proaccelerin, labile factor)
FRZB frizzled-related protein
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
INHBB inhibin, beta B
JADE2 jade family PHD finger 2
KAZN kazrin, periplakin interacting protein
MAP1B microtubule-associated protein 1B
NKX3-1 NK3 homeobox 1
PCDH9 protocadherin 9
PCP4 Purkinje cell protein 4
PDLIM1 PDZ and LIM domain 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PWP1 PWP1 homolog (S. cerevisiae)
RAP1GAP RAP1 GTPase activating protein
RPIA ribose 5-phosphate isomerase A
RUNX3 runt-related transcription factor 3
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
TAGLN transgelin
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TRIM2 tripartite motif containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
Funding