BRD-K19724398_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K19724398_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
AKAP8L A kinase (PRKA) anchor protein 8-like
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD10 ankyrin repeat domain 10
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
AURKA aurora kinase A
BRD2 bromodomain containing 2
CCDC92 coiled-coil domain containing 92
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHPT1 choline phosphotransferase 1
CLU clusterin
COL5A1 collagen, type V, alpha 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
ELOVL5 ELOVL fatty acid elongase 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAS Fas cell surface death receptor
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GSE1 Gse1 coiled-coil protein
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
INPP1 inositol polyphosphate-1-phosphatase
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KIF5C kinesin family member 5C
LPIN2 lipin 2
LPL lipoprotein lipase
MAOB monoamine oxidase B
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCO macrophage receptor with collagenous structure
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLF1 myeloid leukemia factor 1
MMP12 matrix metallopeptidase 12
MYB v-myb avian myeloblastosis viral oncogene homolog
NGRN neugrin, neurite outgrowth associated
ODC1 ornithine decarboxylase 1
PCDH9 protocadherin 9
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PLS1 plastin 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R12A protein phosphatase 1, regulatory subunit 12A
REEP1 receptor accessory protein 1
RGS2 regulator of G-protein signaling 2
RPS27L ribosomal protein S27-like
SESN1 sestrin 1
SSBP2 single-stranded DNA binding protein 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TNS1 tensin 1
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TXNL4B thioredoxin-like 4B
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC14 zinc finger, CCHC domain containing 14

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADD3 adducin 3 (gamma)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
C11ORF71 chromosome 11 open reading frame 71
CADM1 cell adhesion molecule 1
CD36 CD36 molecule (thrombospondin receptor)
CDCA4 cell division cycle associated 4
CHGB chromogranin B
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DEPTOR DEP domain containing MTOR-interacting protein
DST dystonin
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
FCGBP Fc fragment of IgG binding protein
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GPNMB glycoprotein (transmembrane) nmb
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
IL1A interleukin 1, alpha
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
MAGEA12 melanoma antigen family A12
MOK MOK protein kinase
MUC16 mucin 16, cell surface associated
MYOF myoferlin
NLRP2 NLR family, pyrin domain containing 2
NRCAM neuronal cell adhesion molecule
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMM2 phosphomannomutase 2
PRAME preferentially expressed antigen in melanoma
PTHLH parathyroid hormone-like hormone
RAB38 RAB38, member RAS oncogene family
RPL17 ribosomal protein L17
SCAND1 SCAN domain containing 1
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SNAI2 snail family zinc finger 2
TNS3 tensin 3