BRD-K19894101_MST- 312_A549_24.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K19894101_MST- 312_A549_24.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AMOTL2 angiomotin like 2
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BIRC3 baculoviral IAP repeat containing 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNG2 cyclin G2
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCA4 chloride channel accessory 4
CLNS1A chloride channel, nucleotide-sensitive, 1A
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CST3 cystatin C
CSTA cystatin A (stefin A)
CTSK cathepsin K
DCN decorin
DHRS7 dehydrogenase/reductase (SDR family) member 7
DOCK9 dedicator of cytokinesis 9
DUSP6 dual specificity phosphatase 6
EDN3 endothelin 3
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
HIST2H2BE histone cluster 2, H2be
IFI27 interferon, alpha-inducible protein 27
IL1A interleukin 1, alpha
KDM3A lysine (K)-specific demethylase 3A
LAMB3 laminin, beta 3
LAMP2 lysosomal-associated membrane protein 2
LITAF lipopolysaccharide-induced TNF factor
LRP10 low density lipoprotein receptor-related protein 10
MFAP5 microfibrillar associated protein 5
MT1E metallothionein 1E
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
OLFML2A olfactomedin-like 2A
PDGFA platelet-derived growth factor alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PLAT plasminogen activator, tissue
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRNP prion protein
PTN pleiotrophin
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS10 regulator of G-protein signaling 10
RNASET2 ribonuclease T2
RYBP RING1 and YY1 binding protein
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERTAD2 SERTA domain containing 2
SOD2 superoxide dismutase 2, mitochondrial
SPON2 spondin 2, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SRPX sushi-repeat containing protein, X-linked
ST18 suppression of tumorigenicity 18, zinc finger
STAG2 stromal antigen 2
STK17A serine/threonine kinase 17a
SWAP70 SWAP switching B-cell complex 70kDa subunit
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TRAM1 translocation associated membrane protein 1
TRIB3 tribbles pseudokinase 3

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACADVL acyl-CoA dehydrogenase, very long chain
ACSM3 acyl-CoA synthetase medium-chain family member 3
ALOX5 arachidonate 5-lipoxygenase
ATP2A3 ATPase, Ca++ transporting, ubiquitous
C5 complement component 5
CAPN3 calpain 3, (p94)
CCDC86 coiled-coil domain containing 86
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
DZIP3 DAZ interacting zinc finger protein 3
EFNB2 ephrin-B2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FGG fibrinogen gamma chain
FLRT3 fibronectin leucine rich transmembrane protein 3
FMO1 flavin containing monooxygenase 1
FPGS folylpolyglutamate synthase
GAA glucosidase, alpha; acid
GSTA1 glutathione S-transferase alpha 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HGD homogentisate 1,2-dioxygenase
HMG20B high mobility group 20B
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JMJD6 jumonji domain containing 6
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
MCM5 minichromosome maintenance complex component 5
MSRA methionine sulfoxide reductase A
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTS neurotensin
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1 PDZ domain containing 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
RGS4 regulator of G-protein signaling 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
TFF3 trefoil factor 3 (intestinal)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TNS1 tensin 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
VAV3 vav 3 guanine nucleotide exchange factor
Funding