BRD-K20000640_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K20000640_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ADGRG6 adhesion G protein-coupled receptor G6
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ASRGL1 asparaginase like 1
CEMIP cell migration inducing protein, hyaluronan binding
CFI complement factor I
CLDN10 claudin 10
CLIC4 chloride intracellular channel 4
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSG2 desmoglein 2
DST dystonin
DSTN destrin (actin depolymerizing factor)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FNBP1L formin binding protein 1-like
GLRX glutaredoxin (thioltransferase)
HAPLN1 hyaluronan and proteoglycan link protein 1
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KRT18 keratin 18, type I
KRT23 keratin 23, type I
LARS leucyl-tRNA synthetase
LGALS1 lectin, galactoside-binding, soluble, 1
LOC100505650 uncharacterized LOC100505650
MACF1 microtubule-actin crosslinking factor 1
MAP7 microtubule-associated protein 7
MGP matrix Gla protein
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
PAM peptidylglycine alpha-amidating monooxygenase
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSIP1 PC4 and SFRS1 interacting protein 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A4 S100 calcium binding protein A4
SCG2 secretogranin II
SCRG1 stimulator of chondrogenesis 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35F2 solute carrier family 35, member F2
SNX10 sorting nexin 10
SOX4 SRY (sex determining region Y)-box 4
SSFA2 sperm specific antigen 2
SYNM synemin, intermediate filament protein
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM14A transmembrane protein 14A
TMEM230 transmembrane protein 230
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
VNN1 vanin 1
WASF1 WAS protein family, member 1
WWTR1 WW domain containing transcription regulator 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CD8A CD8a molecule
CLU clusterin
CNPY3 canopy FGF signaling regulator 3
COPS7A COP9 signalosome subunit 7A
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
IL7R interleukin 7 receptor
IRX5 iroquois homeobox 5
KLHL21 kelch-like family member 21
NOP2 NOP2 nucleolar protein
RAI14 retinoic acid induced 14
SDC2 syndecan 2
SEPHS1 selenophosphate synthetase 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)